摘要
椎间盘退变是导致发生慢性腰痛的常见原因之一,作为脊柱疾患的常见病,其临床症状主要以腰背部疼痛及功能受限为主,严重影响着人类的身心与健康。因其发病机制复杂,目前尚未充分阐明,对于椎间盘退变的治疗一直是科学研究者及临床工作者关注的焦点。目前关于椎间盘退变的治疗方式主要包括非手术疗法及手术疗法,这些治疗方式可在一定程度上减轻患者的临床症状,但易诱发新的并发症,难以将椎间盘恢复至正常生理功能。近年来,随着基质金属蛋白酶在椎间盘退变组织中的研究不断深入,发现基质金属蛋白酶可作为椎间盘分子治疗靶标,通过降解椎间盘细胞外基质的含量及成分,调节其在椎间盘组织中的表达水平,以此来达到减缓椎间盘退变的进程甚至逆转椎间盘退变的发生。此治疗方式有望延缓因细胞外基质成分或含量改变而造成的椎间盘退变发生。近年来随着网络药理学及生物信息学研究的不断发展,大量研究者对中医药治疗椎间盘退变进行探究,发现中医药可通过抑制基质金属蛋白酶的表达,以此来减少细胞外基质的降解,从而减轻椎间盘退变的症状及减缓椎间盘退变发病进程。笔者就中医药干预基质金属蛋白酶表达治疗椎间盘退变的研究进展作一综述,以期为中医药应用于防治椎间盘退变提供参考和依据。
Intervertebral disc degeneration is one of the common causes of chronic low back pain. As a common spinal disease, its clinical symptoms are mainly low back pain and limited function, which seriously affects physical and psychological health. Because of its complex and unclear pathogenesis, the treatment of intervertebral disc degeneration has been the focus of scientific researchers and clinical workers. At present, the treatment of intervertebral disc degeneration mainly includes non-surgical therapy and surgical therapy, which can alleviate the clinical symptoms of patients to a certain extent, but easily induce new complications, and it is difficult to restore the normal physiological function of the intervertebral disc. In recent years, along with the advanced research on matrix metalloproteinases(MMPs) in the tissues of intervertebral disc degeneration, it has been found that MMPs can be used as molecular therapeutic targets. The expression of MMPs in the intervertebral disc tissues can be regulated by reducing the content and composition of the extracellular matrix of the intervertebral disc, so as to slow down intervertebral disc degeneration and even reverse the occurrence of intervertebral disc degeneration. This treatment is expected to delay intervertebral disc degeneration caused by changes in extracellular matrix composition or content. In recent years, with the continuous development of network pharmacology and bioinformatics research, a large number of researchers have explored the treatment of intervertebral disc degeneration by traditional Chinese medicine(TCM) and found that TCM can reduce the degradation of extracellular matrix by inhibiting the expression of MMPs, thus alleviating the symptoms of intervertebral disc degeneration and slowing down the progression of intervertebral disc degeneration. This paper reviewed the research progress of TCM intervention in MMP expression in the treatment of intervertebral disc degeneration, aiming at providing references for the application of TCM in the prevention and treatment of intervertebral disc degeneration.
作者
赵继荣
杨正汉
马俊飞
陈倩文
张天龙
蒋鹏
赵宁
ZHAO Jirong;YANG Zhenghan;MA Junfei;CHEN Qianwen;ZHANG Tianlong;JIANG peng;ZHAO Ning(Gansu University of Chinese Medicine,Lanzhou 730000,China;Gansu Provincial Hospital of Chinese Medicine,Lanzhou 730050,China)
出处
《中国实验方剂学杂志》
CAS
CSCD
北大核心
2023年第5期272-282,共11页
Chinese Journal of Experimental Traditional Medical Formulae
基金
甘肃省重大项目(21ZD4FA009)
国家中医药管理局项目(GZY-FJS-2020-213)
国家自然科学基金项目(81760877)
兰州市创新人才项目(2018-RC-99)
甘肃省科技厅重点研发计划社会发展类项目(20YF3FA016)。
关键词
中医药
基质金属蛋白酶
椎间盘退变
细胞外基质
traditional Chinese medicine
matrix metalloproteinase
intervertebral disc degeneration
extracellular matrix
