摘要
目的分析糖皮质激素联合沙丁胺醇治疗慢性阻塞性肺疾病(COPD)的临床效果及其对炎性细胞因子水平和肺功能的影响。方法选取2018年1月—2022年6月广东药科大学附属第一医院收治的126例COPD患者作为研究对象,随机分为单一用药组(沙丁胺醇治疗)和联合用药组(糖皮质激素联合沙丁胺醇治疗)各63例,观察两组的临床疗效和治疗期间不良反应发生情况,以及治疗前后炎性细胞因子水平、肺功能情况。结果联合用药组临床总有效率为98.41%,高于单一用药组的87.30%,差异有统计学意义(P<0.05)。治疗后联合用药组白介素-6(IL-6)和C反应蛋白水平较单一用药组低,差异均有统计学意义(P<0.05)。联合用药组第1秒用力呼气容积、用力肺活量和一秒率均高于单一用药组,差异均有统计学意义(P<0.05)。两组均无不良反应发生。结论COPD采用糖皮质激素联合沙丁胺醇治疗安全有效,能够进一步减轻患者的炎症水平,改善肺功能,临床可大力推广。
Objective To analyze the clinical effect of glucocorticoid combined with salbutamol in the treatment of chronic obstructive pulmonary disease(COPD)and its effect on inflammatory cytokines and lung function.Methods A total of 126 patients with COPD admitted to the First Affiliated Hospital of Guangdong Pharmaceutical University from January 2018 to June 2022 were selected as the study objects,and randomly divided into single medication group(salbutamol therapy)and combined medication group(glucocorticoid combined with salbutamol therapy)with 63 cases each.The clinical efficacy and the occurrence of adverse reactions during treatment of the two groups were observed,as well as the levels of inflammatory cytokines and lung function before and after treatment.Results The total clinical effective rate of the combined drug group was 98.41%,which was significantly higher than that of the single drug group(87.30%)(P<0.05).After treatment,the levels of interleukin-6 and C-reactive protein in the combined treatment group were significantly lower than those in the single treatment group(P<0.05).Forced expiratory volume at the first second,forced vital capacity and one-second rate in combined medication group were significantly higher than those in single medication group(P<0.05).No adverse reactions occurred in both groups.Conclusion The treatment of COPD with glucocorticoid combined with salbutamol is safe and effective,which can further reduce the inflammation level of patients and improve lung function,and can be widely promoted in clinic.
作者
康艳虹
冯伟烨
KANG Yanhong;FENG Weiye(Department of Respiratory and Critical Care Medicine,The First Hospital Affiliated to Guangdong Pharmaceutical University,Guangzhou 510000,Guangdong Province,China)
出处
《中国实用乡村医生杂志》
2022年第11期34-36,40,共4页
Chinese Practical Journal of Rural Doctor
关键词
慢性阻塞性肺疾病
药物治疗
糖皮质激素
沙丁胺醇
疗效
炎性因子
肺功能
Chronic Obstructive Pulmonary Disease
Medication
Glucocorticoid
Salbutamol
Curative Effect
Inflammatory Factors
Lung Function
