摘要
目的 在急性酒精中毒患者急诊抢救工作中,为其使用盐酸纳美芬注射液静注治疗,评估该药应用效果及安全性。方法 选择2020年1月—2022年1月本院急诊科诊治的50例急性酒精中毒患者作为研究对象,按照入院序号单双号分为对照组(单序号)和观察组(双序号)两组,每组各25例。全部患者接受急诊科常规干预措施,观察组同时施予盐酸纳美芬注射液治疗。治疗后,评估两组疗效以及患者用药后不良反应、恢复情况(症状消失时间、苏醒时间、运动功能恢复时间)及住院时间;检测患者炎症指标[C反应蛋白(CRP)、白介素-6(IL-6)、肿瘤坏死因子(TNF-α)]、神经递质指标(血清β-内啡肽)、氧化应激反应指标(超氧岐化酶、丙二醛)水平。结果 观察组临床总有效率高于对照组(88.00%&64.00%)(P<0.05)。观察组症状消失时间、苏醒时间、运动功能恢复时间以及患者总住院天数短于对照组(P<0.05)。两组不良反应发生率比较差异无统计学意义(P>0.05)。用药1小时后,两组CRP、IL-6、TNF-α水平均低于用药前,β-内啡肽、丙二醛水平低于用药前,超氧岐化酶水平高于用药前;观察组CRP、IL-6、TNF-α水平低于对照组,观察组血清β-内啡肽、丙二醛水平低于对照组,观察组超氧岐化酶水平高于对照组(P<0.05)。结论 盐酸纳美芬在急性酒精中毒急诊抢救工作中起到重要作用,该药可加快缓解酒精中毒症状,抑制血清炎症及氧化应激反应进展,改善患者神经功能,加快其机体功能恢复。
Objective In the emergency rescue work of clinical intervention for patients with acutealcoholism,nalmefene hydrochloride injection was used for treatment to evaluate the intervention effect and safetyof the drug.Methods 50 cases of patients suffered from acute alcoholism,those were admitted to emergencydepartment of our hospital during January 2020 and January 2022,were enrolled as study subjects.According toserial number and odd number at admission they were divided into control group and observation group,25 cases ineach group.All patients received routine emergency interventions firstly,and patients in the observation group weregiven nalmefene hydrochloride injection on this basis.After treatment,the efficacy,adverse reactions,recovery(symptom disappearance time,recovery time,motor function recovery time) and hospital stay of the two groupswere evaluated.The levels of inflammatory markers [C-reactive protein(CRP),interleukin-6(IL-6),tumornecrosis factor( TNF-α)],neurotransmitter markers( serum β-endorphin) and oxidative stress markers(superoxide dismutase,malondialdehyde) were detected.Results The clinical effective rate of the observationgroup was higher than that of the control group [88.00% & 64.00%](P0.05).After 1 hour of treatment,the levels of CRP,IL-6 and TNF-α in bothtwo groups were lower than those before treatment,the levels of β-endorphin and malondialdehyde were lower thanthose before treatment,while the levels of superoxide dismutase were higher than those before treatment.The levelsof CRP,IL-6 and TNF-α in the observation group were lower than those in the control group,the levels of serumβ-endorphin and malondialdehyde in the observation group were lower than those in the control group,and thesuperoxide dismutase in the observation group was higher than that in the control group(P<0.05).Conclusions Nalmefene hydrochloride plays an important role in the emergency rescue of acute alcoholism.Nalmefenehydrochloride could accelerate the relief of symptoms of alcoholism,inhibit the progression of serum inflammation and oxidative stress reaction,improve the neurological function of patients,and accelerate the recovery of bodyfunction.
作者
赫英春
潘梅珠
He Yingchun;Pan Meizhu(People’s hospital affiliated to Quanzhou Medical College of Fujian province,Quanzhou,Fujian,362000,China;Quanzhou southeast hospital,Quanzhou,Fujian,362000,China)
出处
《齐齐哈尔医学院学报》
2023年第1期22-26,共5页
Journal of Qiqihar Medical University
