摘要
目的 分析脊柱骨肿瘤患者术后1年内复发的相关影响因素。方法 选择87例脊柱骨巨细胞瘤(GCTB)患者,收集患者一般资料,并于术后随访1年,依据患者术后1年内复发与否将其分为复发组与未复发组,分析影响脊柱GCTB患者术后复发的相关因素。结果 87例脊柱GCTB患者术后1年内复发26例,复发率为29.89%(26/87);复发组手术方式为次全椎节切除术、病灶边缘未灭活、术后未放疗、未使用双磷酸盐、侵袭至室间外占比高于未复发组,差异有统计学意义(P<0.05);两组在性别、肿瘤位置、Ennecking分期、术前Frankel分级、手术入路、年龄及肿瘤长径等方面对比,差异无统计学意义(P>0.05);Logistic回归分析显示,手术方式为次全椎节切除、病灶边缘未灭活、术后未放疗、未使用双磷酸盐、侵袭至室间外为影响脊柱GCTB患者术后复发的独立危险因素(P<0.05且OR≥1)。结论 采用次全椎节切除术、侵袭至室间外患者术后复发风险较高,进行病灶边缘灭活、术后放疗、使用双磷酸盐治疗的患者术后复发率较低,分析脊柱GCTB患者术后相关影响因素有利于指导临床制定针对性干预方案,降低术后复发率。
Objective To analyze the related factors of recurrence within 1 year after operation in patients with spinal bone tumors.Methods 87 patients with spinal giant cell tumor(GCTB) were selected.The general data of patients were collected and followed up for 1 year after operation.According to whether the patients relapsed within 1 year after operation, they were divided into recurrence group and non recurrence group, and the related factors affecting the postoperative recurrence of spinal GCTB patients were analyzed.Results 87 patients with spinal GCTB recurred within one year, and the recurrence rate was 29.89%(26/87);The operation methods of recurrent group were subtotal spondylectomy, non inactivation of lesion edge, no postoperative radiotherapy, no bisphosphate, and the proportion of invasion to extraventricular space was higher than that of non recurrent group(P<0.05);There was no significant difference between the 2 groups in gender, tumor location, ennecking stage, preoperative Frankel grade, surgical approach, age and tumor length and diameter(P>0.05);Logistic regression analysis showed that subtotal vertebral resection, non inactivation of lesion edge, no postoperative radiotherapy, no use of bisphosphate and invasion outside the room were the independent risk factors for postoperative recurrence of spinal GCTB patients(P<0.05 and or ≥1).Conclusion The risk of postoperative recurrence is higher in patients with subtotal spondylectomy and invasion to extraventricular patients, and the postoperative recurrence rate is lower in patients with lesion edge inactivation, postoperative radiotherapy and bisphosphate treatment.Analyzing the relevant influencing factors of spinal GCTB patients is helpful to guide the clinical formulation of targeted intervention plan and reduce the postoperative recurrence rate.
作者
赵丹
王高冰
曹倩倩
ZHAO Dan;WANG Gaobing;CAO Qianqian(The First Affiliated Hospital of Zhengzhou University,Zhengzhou,450000)
出处
《实用癌症杂志》
2023年第3期499-501,共3页
The Practical Journal of Cancer
关键词
脊柱骨肿瘤
复发
影响因素
Spinal bone tumor
Recurrence
Influence factor
