摘要
背景:缺氧和炎症通常在许多疾病中同时发生,牙周炎症所处的微环境属于低氧状态,缺氧与HIF通路在牙周组织及牙槽骨代谢过程中起到了关键作用,缺氧微环境所影响到的一系列的重要表型与牙周组织中骨代谢的过程息息相关。目的:探究关于低氧在牙周炎症反应及骨修复和再生中的作用以及所涉及的细胞和分子机制,并简要讨论了低氧模拟剂在牙周骨再生中的应用场景。方法:检索PubMed、中国知网和万方数据库,中文关键词为“低氧、低氧诱导因子1α、牙周炎、骨生成”,英文检索词为“hypoxia;hypoxia inducible factor-1α;periodontitis;osteogenesis”,检索文献年限范围为1990年1月至2022年10月。根据文章内容纳入与文章主题相近或一致的文献,最终共纳入49篇文章进行综述。结果与结论:(1)低氧可引起氧化应激,并使牙周炎症进一步加重;(2)低氧在牙周炎中促进血管生成;(3)低氧可促进牙周膜干细胞的增殖与成骨分化,并同时促进成骨与破骨;(4)通过丰富低氧及HIF通路对牙周组织和骨再生的认识,有助于设计用于加速骨修复和再生的新疗法。
BACKGROUND:Hypoxia and inflammation usually occur together in many diseases.The microenvironment in which periodontal inflammation occurs is hypoxic.Hypoxia and the hypoxia-inducible factor pathway play a key role in the metabolism of periodontal tissue and alveolar bone.OBJECTIVE:To explore the role of hypoxia in periodontal inflammation,bone repair and regeneration and the related cellular and molecular mechanisms and to briefly discuss the application of hypoxia mimetic agents in periodontal bone regeneration.METHODS:PubMed,CNKI and WanFang database were searched for relevant literature published from January 1990 to October 2022.The search words were“hypoxia;hypoxia inducible factor-1α;periodontitis;periodontal;bone;angiogenesis”in Chinese and English,respectively.A total of 49 articles were included for review,based on the content of the articles that were similar or consistent with the topic of the present study.RESULTS AND CONCLUSION:Hypoxia can cause oxidative stress and aggravate periodontal inflammation.Hypoxia promotes angiogenesis in periodontitis.Hypoxia can promote the proliferation and osteogenic differentiation of periodontal stem cells and promote osteogenesis and osteoclast differentiation.It is helpful to design new therapies for accelerating bone repair and regeneration by enriching the understanding of periodontal tissue and bone regeneration through hypoxic and hypoxia-inducible factor pathways.
作者
单超
吴泽钰
赵今
Shan Chao;Wu Zeyu;Zhao Jin(Department of Dentistry and Pulp,The First Affiliated Hospital of Xinjiang Medical University,Urumqi 830011,Xinjiang Uygur Autonomous Region,China;School of Stomatology,Xinjiang Medical University,Urumqi 830011,Xinjiang Uygur Autonomous Region,China)
出处
《中国组织工程研究》
CAS
北大核心
2023年第32期5232-5237,共6页
Chinese Journal of Tissue Engineering Research
基金
自治区区域协同创新专项(科技援疆计划)(2021E01069),项目负责人:赵今。
关键词
牙周炎
缺氧
HIF-1α
低氧诱导因子
骨再生
缺氧模拟剂
骨代谢
periodontitis
hypoxia
HIF-1α
hypoxia-inducible factor
bone regeneration
hypoxia mimetic agent
bone metabolism
