摘要
碘参与甲状腺激素的合成,在人体生命活动中起重要作用。然而,大量证据表明,碘也可参与甲状腺外的其他组织器官的生理和病理过程,对于具有碘摄取功能的组织器官,碘可独立于甲状腺激素发挥抗氧化、促凋亡及促分化等作用,可能对代谢性疾病具有调控作用。近来很多临床研究关注了碘营养与代谢性疾病的相互关系,但受评估碘营养状态的指标不同等多种因素干扰,各研究不能得到统一结论。有必要开展设计严谨的前瞻性研究和基础研究,进一步探索碘与代谢的关系及其作用机制。
Iodine is involved in the synthesis of thyroid hormones and plays an important role in human life.However,considerable evidence indicate that iodine could also be implicated in the physiological and pathological processes of extrathyroidal tissues and organs.Iodine has antioxidant,pro-apoptotic and pro-differentiation effects on organs with iodine uptake capacity independently of thyroid hormones.Iodine may play an important role in regulating of metabolic diseases.Recently,multiple clinical studies focused on the correlation between iodine status and metabolic diseases.However,the results of different studies were inconsistent because different indicators were used in assessing the iodine status.It is necessary to design and conduct prospective studies and basic studies to further explore the relationship and mechanism between iodine and metabolic diseases.
作者
翟晓丹
单忠艳
李玲
Zhai Xiaodan;Shan Zhongyan;Li Ling(Department of Endocrinology and Metabolism,Shengjing Hospital of China Medical University,Shenyang 110004,China;Department of Endocrinology and Metabolism,The First Hospital of China Medical University,Shenyang 110001,China)
出处
《国际内分泌代谢杂志》
2023年第1期26-29,共4页
International Journal of Endocrinology and Metabolism
关键词
碘
代谢性疾病
肥胖
血脂异常
抗氧化
Iodine
Metabolic diseases
Obesity
Dyslipidemia
Antioxidant
