摘要
黄药子具有很长的药用历史,临床应用广泛,且具有显著的抗肿瘤、抗炎、抗菌、抗氧化以及免疫调节等功能。现通过综述黄药子毒性成分,并从肝毒性、肾毒性、胃肠系统毒性、甲状腺毒性等多个方面总结其毒性机制,为黄药子的毒理学评价提供依据以及为后期药物临床应用提供参考。
Dioscorea bulbifera L.has a long history of medicinal use and is widely used in clinic,and has significant anti-tumor,anti-inflammatory,antibacterial,antioxidant and immune regulation functions.In this paper,the toxic components of Dioscorea bulbifera L.are reviewed,and its toxic mechanism is summarized from hepatotoxicity,nephrotoxicity,gastrointestinal toxicity,thyroid toxicity and other aspects,so as to provide basis for toxicological evaluation of Dioscorea bulbifera L.and provide reference for later clinical application of drugs.
作者
张盼盼
仵琼
葛肖肖
王乐
张雨轩
谢允东
ZHANG Panpan;WU Qiong;GE Xiaoxiao;WANG Le;ZHANG Yuxuan;XIE Yundong(Shaanxi University of Chinese Medicine,Shaanxi Xianyang 712046,China)
出处
《现代中医药》
CAS
2023年第2期8-12,共5页
Modern Chinese Medicine
基金
国家自然科学基金项目(82204790)
陕西省自然科学基础研究计划项目(2021JQ-730)
陕西省教育厅专项科研计划项目(21JK0598)。
关键词
黄药子
毒性
毒性机制
临床应用
Dioscorea bulbifera L.
Toxicity
Toxicity mechanism
Clinical application
