摘要
目的 分析双歧杆菌乳杆菌三联活菌片联合康复新液防治宫颈癌急性放射性肠炎的临床疗效。方法 2020年1月至2022年6月盐城市第二人民医院放疗科52例宫颈癌放射治疗患者随机分为观察组和对照组,每组26例,观察组在放疗开始时予以双歧杆菌乳杆菌三联活菌片口服,并配合康复新液每晚保留灌肠,对照组在出现明显肠道反应时常规予以消炎药及激素静脉滴注治疗。结果 观察组急性肠炎0~1级、2级、3级反应分别为23例、3例、0例,对照组为17例、5例、4例,差异具有统计学意义(Z=-3.002,P=0.003)。观察组急性肠炎出现时间为(18.7±2.7)天,对照组为(11.5±2.6)天,差异具有统计学意义(P <0.05)。治疗后观察组与对照组治疗后hs-CRP比较,差异具有统计学意义(P <0.05)。结论 宫颈癌患者放射治疗过程中及早予以双歧杆菌乳杆菌三联活菌片口服调节肠道菌群、康复新液灌肠修复损伤黏膜,可延缓急性放射性肠炎出现时间,减轻肠道症状,hs-CRP可作为炎症状态的监测指标。
Objective To analyze the clinical efficacy of live combined Bifidobacterium and Lactobacillus tablets combined with kangfuxin liquid in the prevention and treatment of acute radiation-induced enteritis in cervical cancer. Methods From January 2020 to June 2022, 52 patients with cervical cancer undergoing radiotherapy in the Yancheng Second People’s Hospital, were randomly divided into the observation group and the control group, with 26 patients in each group. The observation group was given bifidobacterium lactobacillus triple viable tablets orally at the beginning of radiotherapy, and with a nightly retention enema with Kangfuxin liquid, and the control group was given anti-inflammatory drugs and hormone intravenous drip treatment when obvious intestinal reactions occurred. Results There were 23, 3 and 0 patients with grade 0~1, 2 and 3 acute enteritis in the observation group, and 17 cases, 5 cases and 4 cases in the control group, respectively, the difference was statistically significant(Z=-3.002, P=0.003). The onset time of acute enteritis was(18.7±2.7) days in the observation group and(11.5±2.6) days in the control group,presenting a statistically significant difference(P<0.05). hs-CRP showed a statistically significant difference between the observation group and the control group after treatment(P<0.05). Conclusion Early oral administration of live combined bifidobacterium and lactobacillus tablets to regulate the intestinal flora and kangfuxin liquid enema to repair the damaged mucosa in patients with cervical cancer during radiotherapy can delay the occurrence of acute radiation-induced enteritis and relieve intestinal symptoms. Additionally, hs-CRP can be used as a monitoring indicator for the inflammatory state.
作者
姚钧
YAO Jun(Department of Radiotherapy,Yancheng Second People's Hospital,Yancheng 224003 China)
出处
《中国医药指南》
2023年第6期34-37,共4页
Guide of China Medicine
关键词
双歧杆菌乳杆菌三联活菌片
康复新液
宫颈癌
急性放射性肠炎
Live combined bifidobacterium and lactobacillus tablets
Kangfuxin liquid
Cervical cancer
Acute radiation-induced enteritis
