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紫术消瘤散对不同类型宫颈HR-HPV持续感染的临床疗效分析 被引量:3

Clinical Efficacy of Zizhu Xiaoliu Powder in Treatment of Different Types of Cervical HR-HPV Persistent Infection
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摘要 目的:研究紫术消瘤散对不同类型宫颈高危型人乳头瘤病毒(HR-HPV)持续感染的临床疗效。方法:将120例符合纳入标准的HR-HPV持续感染患者随机分为治疗组和对照组,每组各60例。对照组使用重组人干扰素α-2b阴道泡腾胶囊进行治疗,治疗组使用紫术消瘤散于宫颈处上药,均治疗3个月经周期。疗程结束后,比较两组患者治疗前后HR-HPV病毒载量和中医证候积分的变化情况,并比较临床有效率。结果:治疗后,治疗组中HPV16/18型感染者、其他12种HR-HPV感染者的病毒载量均较治疗前明显下降,差异有统计学意义(P<0.05)。治疗组中HPV16/18型感染者痊愈率68.42%(13/19)与对照组痊愈率58.82%(10/17)比较,差异无统计学意义(P>0.05),但显效率21.05%(4/19)优于对照组0%(0/17)(P<0.05);治疗组中其他12种HR-HPV感染者痊愈率为63.04%(29/46)优于对照组的41.51%(22/53)(P<0.05)。在中医证候疗效方面,治疗组的显效率47.37%(27/57)高于对照组28.33%(17/60)(P<0.05)。结论:紫术消瘤散能有效降低湿热瘀结型HR-HPV持续感染患者的病毒载量,对其他12种HRHPV感染者的治疗效果更佳,HPV16/18感染者可能需要延长治疗时间以提高疗效。 Objective:To explore the clinical efficacy of Zizhu Xiaoliu Powder in treatment of cervical high-risk human papilloma virus(HR-HPV)persistent infection.Methods:A total of 120 cases of cervical HR-HPV persistent infection were randomly divided into the control group(n=60)and the treatment group(n=60).The control group was treated with Recombinant Human Interferonα-2b Vaginal Effervescent Capsule,and the treatment group was treated with Zizhu Xiaoliu Powder by cervical administration.The treatment course was 3 menstrual cycles.The changes in viral load of HR-HPV,clinical efficacy and TCM symptoms score were compared between before and after the treatment in the two groups.The clinical efficacy was also compared between the two groups.Results:After the treatment,the viral loads of HPV16/18 infections and other HR-HPV types of infections were significantly decreased compared with those before the treatment in the treatment group(P<0.05).The healing rate of HPV16/18 was 68.42%(13/19)in the treatment group,which was higher than 58.82%(10/17)in the control group,but in which there was no statistical difference between the two groups(P>0.05).The excellent effective rate was 21.05%(4/19)in the treatment group,which was significantly higher than 0%(0/17)in the control group(P<0.05).The healing rate of other HR-HPV types was 63.04%(29/46)in the treatment group,which was higher than 41.51%(22/53)in the control group(P<0.05).The excellent effective rate of the treatment group was 47.37%(27/57),which was better than 28.33%(17/60)of the control group in term of TCM clinical efficacy(P<0.05).Conclusion:Zizhu Xiaoliu Powder can effectively reduce the viral load in cervical HR-HPV persistent infections with damp-heat and stasis syndrome,it has better effects on other 12 kinds of HR-HPV,and it needs prolonging treating time to improve efficacy for HPV16/18 infection.
作者 刘倩 刘用诚 詹炳南 吴冬梅 LIU Qian;LIU Yongcheng;ZHAN Bingnan;WU Dongmei(The Second People's Hospital Affiliated to Fujian University of Traditional Chinese Medicine,Fuzhou 350003,China;XIE Decong's Famous Traditional Chinese Medicine Inheritance Studio,Fuzhou 350003,China;The Third People's Hospital of Fujian University of Traditional Chinese Medicine,Fuzhou 350122,China)
出处 《中医药信息》 2023年第3期62-66,共5页 Information on Traditional Chinese Medicine
基金 国家中医药管理局第五批全国中医临床优秀人才研修项目(国中医药人教函[2022]1号) 福建省卫生健康委员会医学创新课题(2020CXA051)。
关键词 紫术消瘤散 高危型人乳头瘤病毒 持续感染 疗效 Zizhu Xiaoliu Powder HR-HPV Persistent infection Clinical effect
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