摘要
目的:观察利奈唑胺联合莫西沙星治疗结核性脑膜炎患者的效果。方法:回顾性分析2016年7月至2021年7月该院收治的60例结核性脑膜炎患者的临床资料,按治疗方法不同将其分为对照组和观察组各30例。两组均采用抗结核药物治疗,在此基础上,对照组采用莫西沙星治疗,观察组在对照组基础上联合利奈唑胺治疗,比较两组治疗前后脑脊液指标[白细胞计数、蛋白定量、葡萄糖、脑脊液压力、神经元特异性烯醇化酶(NSE)、神经生长因子(NGF)]水平,血清内皮素水平,炎性因子[白细胞介素-4(IL-4)、白细胞介素-2(IL-2)、C反应蛋白(CRP)]水平,以及不良反应发生率。结果:治疗后1周,两组白细胞计数、脑脊液压力、蛋白定量、NSE水平均低于治疗前,且观察组低于对照组,两组葡萄糖、NGF水平均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05);治疗后1周,两组血清内皮素、IL-4、IL-2和CRP水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:利奈唑胺联合莫西沙星治疗结核性脑膜炎患者可改善脑脊液指标水平,降低血清内皮素和炎性因子水平,效果优于单纯莫西沙星治疗。
Objective:To observe effects of Linezolid combined with Moxifloxacin in treatment of patients with tuberculous meningitis.Methods:The clinical data of 60 patients with tuberculous meningitis admitted to this hospital from July 2016 to July 2021 were retrospectively analyzed.They were divided into control group and observation group according to different treatment methods,30 cases in each.Both groups were treated with anti-tuberculosis drugs.On this basis,the control group was treated with Moxifloxacin,while the observation group was treated with Linezolid on the basis of that of the control group.The levels of cerebrospinal fluid indexes[white blood cell count,protein quantification,glucose,cerebrospinal fluid pressure,neuron-specific enolase(NSE),nerve growth factor(NGF)],the serum endothelin level,the inflammatory factor levels[interleukin-4(IL-4),interleukin-2(IL-2),C-reactive protein(CRP)],and the incidence of adverse reactions were compared between the two groups before and after the treatment.Results:1 week after the treatment,the levels of white blood cell count,cerebrospinal fluid pressure,protein quantification and NSE in the two groups were lower than those before the treatment,and those in the observation group were lower than those in the control group;the levels of glucose and NGF in the two groups were higher than those before the treatment,and those in the observation group were higher than those in the control group;and the differences were statistically significant(P<0.05).1 week after the treatment,the levels of serum endothelin,IL-4,IL-2 and CRP in the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Linezolid combined with Moxifloxacin in the treatment of tuberculous meningitis can improve the levels of cerebrospinal fluid indexes,and reduce the levels of serum endothelin and inflammatory factors.Moreover,it is superior to single Moxifloxacin treatment.
作者
叶远飞
卢飞燕
陈俏
YE Yuanfei;LU Feiyan;CHEN Qiao(Department of Tuberculosis of the Fifth People’s Hospital of Ganzhou,Ganzhou 341000 Jiangxi,China)
出处
《中国民康医学》
2023年第3期18-20,共3页
Medical Journal of Chinese People’s Health
关键词
结核性脑膜炎
利奈唑胺
莫西沙星
炎性因子
脑脊液
不良反应
Tuberculous meningitis
Linezolid
Moxifloxacin
Inflammatory factor
Cerebrospinal fluid
Adverse reaction
