摘要
目的 通过分析血清抗苗勒氏管激素(AMH)、基础性激素六项在多囊卵巢综合征(PCOS)患者与健康查体者的表达水平比较,为PCOS的诊断提供临床依据.方法 选取2021年1月-2022年1月,临床诊断为多囊卵巢综合征的44例女性患者为实验组,并选取同期健康查体女性40例为对照组.比较实验组及对照组AMH、性激素六项:促黄体生成素(LH)、雌二醇(E2)、催乳素(PRL)、睾酮(T)、孕酮(PROG)、促卵泡激素(FSH)指标,分析PCOS患者中AMH、性激素六项的相关性,绘制ROC曲线并计算出PCOS的cutoff的值.结果 ①实验组血清AMH、LH、E2、PRL、T、PROG水平高于对照组,FSH水平低于对照组,两组比较,差异有统计学意义的有:AMH、LH、PROG、T(P<0.05).无统计学差异的有:E2、PRL、FSH(P>0.05).②pearson相关性分析显示:AMH与T呈中等相关,与LH呈强相关(P<0.01),与PROG无显著差异.③诊断PCOS的AUC分别为AMH:0.894,LH:0.814,T:0.815,PROG:0.497,血清AMH诊断PCOS的诊断价值最高.结论 通过比较PCOS患者与健康女性血清AMH、性激素六项显示,PCOS患者的血清AMH显著升高.其中性激素六项中具有统计学意义有:LH、PROG、T(P<0.05).在PCOS患者中,LH、PROG、T均升高,其E2、PRL、FSH无统计学意义(P>0.05).采用ROC曲线确定,当AMH的cutoff为0.894时,PCOS的诊断具有临床意义.
Objective To provide clinical basis for the diagnosis of polycystic ovary syndrome(PCOS)by analyzing the expression levels of six serum anti Mullerian hormone(AMH)and basic hormone in patients with PCOS and healthy patients.Methods 44 female patients clinically diagnosed with PCOS from January 2021 to January 2022 were selected as the experimental group,and 40 healthy women were selected as the control group.The six indexes of AMH and sex hormone:luteinizing hormone(LH),estradiol(E2),prolactin(PRL),testosterone(T),progesterone(PROG)and follicle stimulating hormone(FSH)in the experimental group and the control group were compared to analyze the correlation of the six indexes of AMH and sex hormone in PCOS patients,draw the ROC curve to calculate the cutoff value of PCOS.Results The serum levels of AMH,LH,E2,PRL,T and PROG in the experimental group were higher than those in the control group,and the level of FSH was lower than that in the control group(P<0.05).E2,PRL and FSH have no statistical difference(P>0.05).②Pearson correlation analysis showed that AMH was moderately correlated with T and strongly correlated with LH(P<0.01).There was no significant difference with prog.③The AUCs of diagnosis of PCOS were AMH:0.894,LH:0.814,T:0.815,PROG:0.497,respectively.Serum AMH has the highest diagnostic value for PCOS.Conclusion By comparing six items of serum AMH and sex hormone between PCOS patients and healthy women,the serum AMH of PCOS patients is significantly higher.Among the six sex hormones,LH,PROG and T were statistically significant(P<0.05).LH,PROG and T were elevated in PCOS patients.PRL and FSH had no statistical significance(P>0.05).ROC curve was used to establish that when the cutoff of AMH was 0.894,the diagnosis of PCOS was of clinical significance.
作者
唐晓聪
Tang Xiaocong(Department of medical laboratory,the Fourth Affiliated Hospital of Guangxi Medical University,Liuzhou,Guangxi 545005,China)
出处
《首都食品与医药》
2023年第4期74-76,共3页
Capital Food Medicine
