摘要
目的 探讨前哨淋巴结活检联合保乳手术对乳腺癌患者糖类抗原125(CA125)、癌胚抗原(CEA)及人表皮生长因子受体2(HER-2)表达的影响。方法 入选本院2019年1月至2022年1月收治的乳腺癌患者70例为研究对象,按照不同治疗方案均分为两组,观察组35例患者予以保乳联合前哨淋巴结活检术治疗,对照组35例患者实施腋窝淋巴结清扫术。比较两组肩关节功能优良率,手术情况,生活质量评分,血清肿瘤标记物,HER-2表达及并发症发生率。结果 观察组优良率(97.14%)显著高于对照组(74.29%)(P<0.05);观察组手术时间、住院时间、总出血量、总引流量显著低于对照组(P<0.05);观察组心理功能、社会功能、生活状态、躯体功能评分显著高于对照组(P<0.05);观察组术后CA125、CEA水平显著低于对照组(P<0.05);两组HER-2表达情况比较,无显著差异(P>0.05);观察组并发症发生率(0%)显著低于对照组(20.00%),有统计学意义(P<0.05)。结论 保乳手术结合前哨淋巴结活检治疗,创伤更小,能够有效改善患者肩关节功能,降低血清肿瘤标志物水平,还能保持乳房形态,提高患者生活质量。
Objective To investigate the effects of sentinel lymph node biopsy combined with breast-conserving surgery on the expression of carbohydrate antigen 125(CA125), carcinoembryonic antigen(CEA)and human epidermal growth factor receptor 2(HER-2)in breast cancer patients.Methods A total of 70 patients with breast cancer admitted to our hospital from January 2019 to January 2022 were selected as research objects.They were divided into two groups according to different treatment plans. 35 patients in the observation group were treated with breast conserving combined with sentinel lymph node biopsy, and 35 patients in the control group were treated with axillary lymph node dissection. The good and good rate of shoulder joint function, operation, quality of life score, serum tumor markers, HER-2 expression and complication rate were compared between the two groups. Results The excellent and good rate of observation group(97.14%)was significantly higher than that of control group(74.29%)( P<0.05). Operation time, hospital stay, total blood loss and total drainage volume in observation group were significantly lower than those in control group(P<0.05). The scores of psychological function, social function, living status and physical function in the observation group were significantly higher than those in the control group(P<0.05). The levels of CA125 and CEA in observation group were significantly lower than those in control group( P<0.05). There was no significant difference in the expression of HER-2 between the two groups( P>0.05). The complication rate of observation group(0%)was significantly lower than that of control group(20.00%), with statistical significance( P<0.05). Conclusion Breast-conserving surgery combined with sentinel lymph node biopsy treatment has less trauma, can effectively improve the shoulder joint function of patients, reduce the level of serum tumor markers, maintain the shape of the breast, and improve the quality of life of patients.
作者
徐甜甜
雷桂梅
麻继元
XU Tiantian;LEI Guimei;MA Jiyuan(Lishui Maternity and Child Health Hospital,Lishui,Zhejiang,323000,China)
出处
《浙江创伤外科》
2023年第3期426-429,共4页
Zhejiang Journal of Traumatic Surgery
关键词
乳腺癌
前哨淋巴结活检
保乳手术
Breast cancer
Sentinel lymph node biopsy
Breast conserving surgery
