摘要
目的:分析患者进入重症监护病房(ICU)24 h内的多元维生素水平及缺乏症,并进行临床相关性研究。方法:收集2022年2月~11月南京鼓楼医院收治的369例成人重症患者的临床数据,分析患者多元维生素水平及其与C反应蛋白(CRP)、序贯器官衰竭评分(SOFA)和全因死亡率等之间的相关性。结果:重症患者VA、VD和VE缺乏症的发生率分别为42.01%、87.26%和22.49%。患者体内VA水平和CRP水平相关(P <0.05)。VA、VD和VE水平之间呈正相关(P <0.001)。VA和VD水平与SOFA呈负相关(P <0.05)。369例患者中死亡85例,总体死亡率23.04%,死亡组患者的VA和VD水平以及VD缺乏症的发生率显著低于存活组(P <0.05),VD缺乏、VA水平降低、VD水平降低、SOFA增加和机械通气时间延长为患者ICU住院期间全因死亡的相关因素。结论:重症患者普遍存在维生素缺乏,VA和VD水平与患者的预后相关,需要进一步研究维生素在重症患者中的作用。
Objective: To analyze the multivitamin level and deficiency of patients within 24 h after admission to the intensive care unit(ICU), and to conduct clinical correlation study. Methods: Clinical data of 369 severe adult patients admitted to Nanjing Drum Tower Hospital from February to November 2022 were collected, and the correlations between multivitamin levels and C-reactive protein(CRP),sequential organ failure assessment(SOFA) and all-cause mortality were analyzed. Results: The incidence of vitamin A, D and E deficiency in severe patients were 42.01%, 87.26% and 22.49%, respectively.Vitamin A levels were correlated with C-reactive protein levels(P < 0.05). There were positive correlations between vitamin A, D and E levels(P < 0.001). The levels of vitamin A and D were negatively correlated with SOFA(P < 0.05). Of the 369 patients, 85 died, with an overall mortality of 23.04%. The levels of vitamin A and D and the incidence of vitamin D deficiency in the death group were significantly different from those in the survival group(P < 0.05). Vitamin D deficiency, decreased vitamin A and D levels,increased SOFA score, and prolonged mechanical ventilation were relevant factors for all-cause death during ICU stay. Conclusion: Vitamin deficiency is common in critically ill patients, and vitamin A and D levels are associated with the prognosis of patients. Further studies are needed to investigate the role of vitamins in critical patients.
作者
潘欢妍
徐颖
梁培
卢张阳
王倩
李俐
PAN Huanyan;XU Ying;LIANG Pei;LU Zhangyang;WANG Qian;LI Li(Nanjing Drum Tower Hospital,China Pharmaceutical University,Nanjing 210009,China;School of Basic Medicine and Clinical Pharmacy,China Pharmaceutical University,Nanjing 210009,China;Department of Pharmacy,Nanjing Drum Tower Hospital,Nanjing 210008,China;Department of Critical Care Medicine,Nanjing Drum Tower Hospital,Nanjing 210008,China)
出处
《药学与临床研究》
2023年第1期37-42,共6页
Pharmaceutical and Clinical Research
关键词
维生素缺乏
重症患者
微量营养素
死亡
Vitamin deficiency
Critically ill patients
Micronutrients
Death
