摘要
目的探讨桥本甲状腺炎(HT)并发分化型甲状腺癌(DTC)患者手术前后甲状腺球蛋白抗体(TGAb)、抗甲状腺过氧化酶抗体(TPO-Ab)及血清炎性因子水平及意义。方法选取2019年1月至2021年1月在河北中石油中心医院就诊的DTC患者141例,根据术后病理检查是否合并HT分为:DTC合并HT患者43例和DTC患者98例,比较两组患者临床病理特征、TGAb、TPO-Ab、促甲状腺素(TSH)等差异。结果DTC合并HT组女性比例、病理分期I~II比例明显高于DTC未合并HT组,差异比较有统计学意义(P<0.05),而肿瘤最大径明显低于DTC未合并HT组,差异比较有统计学意义(P<0.05)。DTC合并HT组治疗前TSH、TGAb和TPO-Ab明显高于DTC未合并HT组,差异比较有统计学意义(P<0.05),治疗后TSH、TGAb和TPO-Ab明显低于DTC未合并HT组,差异比较有统计学意义(P<0.05)。DTC合并HT组术后复发率明显高于DTC未合并HT组,差异有统计学意义(P<0.05)。复发患者病理分期III~IV比例明显高于未复发患者,差异比较有统计学意义(P<0.05);复发患者治疗前TGAb、TPO-Ab明显高于未复发患者,差异比较有统计学意义(P<0.05)。结论相比较单纯DTC,HT合并DTC病理分期处于早期水平,并未增加肿瘤侵袭性,血清TSH、TGAb和TPO-Ab水平升高,血清炎性因子水平无特异性,其中术前TGAb和TPO-Ab高水平可作为手术预后与复发的参考指标。
Objective To investigate levels and significances of thyroglobulin antibody(TGAb),thyroid peroxidase antibody(TPO-Ab)and serum inflammatory factors in patients with HT(Hashimoto’s thyroiditis)complicated with DTC(differentiated thyroid cancer)before and after surgery.Methods 141 patients with DTC treated in Hebei PetroChina Central Hospital from January,2019 to January,2021 were selected for the study.According to the postoperative pathological examination results,all patients were divided into groups as:43 patients with DTC combined with HT and 98 patients with DTC.The clinicopathological features,TGAb,TPO-Ab and thyroid stimulating hormone(TSH)between the two groups were the compared.Results The proportion of women,the proportion of pathological stages I-II in the DTC combined with HT group were significantly higher than those in the DTC without HT group(P<0.05),while the maximum diameter of tumor was significantly lower than that in the DTC without HT group(P<0.05).TSH,TGAb and TPO-Ab in the DTC combined with HT group before treatment were significantly higher than those in the DTC without HT group(P<0.05).TSH,TGAb and TPO-Ab after treatment were significantly higher than those in the DTC without HT group(P<0.05).The postoperative recurrence rate of DTC combined with HT group was significantly higher than that of DTC without HT group(P<0.05).The proportion of pathological stages III-IV in recurrent patients was significantly higher than that in non-recurrent patients(P<0.05).TGAb and TPO-Ab in recurrent patients before treatment were significantly higher than those in non-recurrent patients(P<0.05).Conclusion Compared with simple DTC,the pathological stage of HT combined with DTC is at an early stage level,which does not increase tumor invasiveness,while levels of serum TSH,TGAb and TPO-Ab are increased,and levels of serum inflammatory factors are not specific.The high levels of TGAb and TPO-Ab before surgery can be used as reference indexes for prognosis and recurrence.
作者
高峰
吕金
王子斌
卢伟燕
姜玉石
GAO Feng;LYU Jin;WANG Zibin;LU Weiyan;JIANG Yushi(General Surgery,Hebei PetroChina Central Hospital,Langfang 065000,China)
出处
《标记免疫分析与临床》
CAS
2023年第1期106-111,共6页
Labeled Immunoassays and Clinical Medicine
基金
河北省廊坊市科学技术研究与发展计划项目(编号:2021013153)。
关键词
桥本甲状腺炎
分化型甲状腺癌
甲状腺球蛋白抗体
抗甲状腺过氧化酶抗体
炎性因子
Hashimoto’s thyroiditis
Differentiated thyroid carcinoma
Thyroglobulin antibody
Anti thyroid peroxidase antibody
Inflammatory factor
