摘要
目的探究单纯性先天性上睑下垂的危险因素。方法采用病例对照研究方法,选取2018年10月至2021年1月于浙江大学医学院附属第二医院就诊的单纯性先天性上睑下垂患儿106例为病例组,以同期无先天性异常且性别相匹配的儿童106例为对照组。对所有受检者进行睑裂高度、睑缘反射点距离1等眼科检查,并对患儿母亲进行问卷调查。问卷内容包括:人口统计信息、妊娠期疾病史和妊娠期医疗及环境暴露情况。采用单变量分析比较病例组与对照组间各变量的差异。将P<0.20的变量纳入多因素Logistic回归分析单纯性先天性上睑下垂的危险因素。模型拟合度采用Hosmer-Lemeshow检验,以方差扩大因子(VIF)评价各因素的共线性。结果病例组与对照组孕周<37周、胎次≥2次、母亲年龄、孕早期抗生素药物摄入、父亲吸烟≥半包/d以及妊娠期母亲被动吸烟例数比较,均P<0.20。多因素Logistic回归分析结果显示,孕周<37周[比值比(OR)=4.58;95%置信区间(CI):1.24~16.85],父亲吸烟≥半包/d(OR=2.28;95%CI:1.22~4.28)以及母亲妊娠期被动吸烟(OR=3.13;95%CI:1.16~8.41)是单纯性先天性上睑下垂的危险因素。各个危险因素之间无显著共线性关系(均VIF<5)。结论早产、父亲吸烟、母亲妊娠期被动吸烟是单纯性先天性上睑下垂的独立危险因素。
Objective To identify the risk factors for simple congenital ptosis.Methods A case-control study was performed.A total of 106 children diagnosed with simple congenital ptosis at the Second Affiliated Hospital of Zhejiang University School of Medicine from October 2018 to January 2021 were recruited as a case group,and 106 sex-matched children without congenital abnormalities were enrolled as a control group at the same period.Ophthalmic examinations,including interpalpebral fissure height and margin reex distance 1,were performed on all participants.A questionnaire survey was administered to their mothers.The questionnaire included demographic information,prenatal maternal diseases,medical treatments and environmental exposures during pregnancy.Univariate analysis was used to compare the differences in variables between the case and control groups.Variables with P<0.20 were retained for multivariate logistic regression analysis to identify the risk factors for simple congenital ptosis.The goodness of fit of the model was evaluated by the Hosmer-Lemeshow test,and collinearity was assessed by the variance inflation factor(VIF).This study adhered to the Declaration of Helsinki.The study protocol was approved by the Ethics Committee of the Second Affiliated Hospital of Zhejiang University School of Medicine(No.2019-136).The method and purpose of the study were fully explained to the children's guardians and written informed consent was obtained.Results Comparisons of gestational age<37 weeks,birth order≥2,maternal age,antibiotic use in the first trimester,paternal smoking≥half a pack per day,and prenatal maternal passive smoking between the two groups were all with P<0.20.Multivariate logistic regression analysis showed that gestational age<37 weeks(odds ratio[OR]=4.58;95%confidence interval[CI]:1.24-16.85),paternal smoking≥half a pack per day(OR=2.28;95%CI:1.22-4.28)and prenatal maternal passive smoking(OR=3.13;95%CI:1.16-8.41)were risk factors for simple congenital ptosis.No significant collinearity was found among these identified factors(all VIF<5).Conclusions Preterm birth,paternal smoking,and prenatal maternal passive smoking are risk factors for simple congenital ptosis.
作者
邵霁
汪伊洁
楼丽霞
徐宇峰
叶娟
Shao Ji;Wang Yijie;Lou Lixia;Xu Yufeng;Ye Juan(Department of Ophthalmology,the Second Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310009,China)
出处
《中华实验眼科杂志》
CAS
CSCD
北大核心
2023年第3期266-270,共5页
Chinese Journal Of Experimental Ophthalmology
基金
国家自然科学基金区域创新发展联合基金项目(U20A20386)
浙江省眼部疾病临床医学研究中心项目(2021E50007)。
关键词
先天性上睑下垂
危险因素
早产
吸烟
Congenital ptosis
Risk factors
Preterm birth
Smoking
