摘要
自身免疫性肝炎作为一种由免疫耐受缺失导致的慢性肝脏炎症,其发病受多种信号通路的调控,例如NF-κB/NLRP3通路、SIRT1/Nrf2/HO-1通路、Hippo-YAP/TAZ通路、JAK/STAT通路、PI3K/Akt通路和TRAF6/JNK通路等,这些通路能够通过参与细胞因子的增殖和凋亡、免疫反应以及氧化应激等过程来发挥抗免疫性肝炎的作用。针对临床应用激素和免疫制剂治疗自身免疫性肝炎出现的应答不佳、不良反应明显及复发率高等问题,本文对自身免疫性肝炎相关信号传导通路的研究文献进行了总结,并梳理了苷类、萜类、黄酮类、醌类及酚类中药有效成分通过以上信号通路干预自身免疫性肝炎疾病进程的机制,以期为科学有效地利用中药有效成分研发抗自身免疫性肝炎药物提供理论参考依据。
As a chronic liver inflammation disease caused by the lack of immune tolerance,autoimmune hepatitis is regulated by various signaling pathways,such as the NF-κB/NLRP3 pathway,the SIRT1/Nrf2/HO-1 pathway,the Hippo-YAP/TAZ pathway,the JAK/STAT pathway,the PI3K/Akt pathway,and the TRAF6/JNK pathway.These pathways can play a role against autoimmune hepatitis by participating in the processes including the proliferation and apoptosis of cytokines,immune response,and oxidative stress.In view of the problems of suboptimal response,obvious adverse reactions,and high recurrence rate in the clinical application of hormones and immune preparations for the treatment of autoimmune hepatitis,this article summarizes the research articles on autoimmune hepatitis-related signaling pathways and the mechanism of effective constituents(glycosides,terpenoids,flavonoids,quinones,and phenols)in traditional Chinese medicine intervening against the disease process of autoimmune hepatitis through the above signaling pathways,in order to provide a theoretical basis for scientific and effective utilization of effective constituents in traditional Chinese medicine to develop anti-autoimmune hepatitis drugs.
作者
郝君玉
刘光伟
谢露
范文艳
陈虹秀
HAO Junyu;LIU Guangwei;XIE Lu;FAN Wenyan;CHEN Hongxiu(The First Clinical Medical College of Henan University of Traditional Chinese Medicine,Zhengzhou 450000,China;Department of Hepatology and Spleen-Stomach,The First Affiliated Hospital of Henan University of Traditional Chinese Medicine,Zhengzhou 450000,China)
出处
《临床肝胆病杂志》
CAS
北大核心
2023年第3期663-670,共8页
Journal of Clinical Hepatology
基金
国家自然科学基金资助项目(81573933)
河南省自然科学基金(222300420490)
河南省特色骨干学科中医学学科建设项目(STG-ZYXKY-2020017)。
关键词
肝炎
自身免疫性
中草药
信号传导
Hepatitis,Autoimmune
Drugs,Chinese Herbal
Signal Transduction
