摘要
目的探讨H型高血压与心血管介入术后对比剂肾病(CIN)的发生是否存在相关性。方法回顾性分析湖北省中西医结合医院2020年5月~2021年8月期间接受心血管介入治疗的342例原发性高血压患者的临床资料。根据血清同型半胱氨酸(Hcy)水平分为H型高血压组(Hcy≥10μmol/L,共计206例)和非H型高血压组(Hcy<10μmol/L,共计136例),比较患者的临床基线资料、术后肾功能血清肌酐(Scr)、估算的肾小球滤过率(eGFR)及CIN发生率的差异,并采用Logistic回归分析探讨心血管介入术后发生CIN的危险因素。结果342例患者心血管介入术后共发生CIN 24例,占比7.02%。H型高血压组的CIN发生率(9.71%)高于非H型高血压组(2.94%),差异有统计学意义(P<0.05)。术后,H型高血压组血清Scr水平高于非H型高血压组,eGFR低于非H型高血压组,差异均有统计学意义(P<0.05)。多因素Logistic回归分析显示:与非H型高血压组对比,H型高血压组发生CIN的风险显著增加(OR=1.189,95%CI:1.023~1.383,P=0.024)。结论H型高血压可能是心血管介入后CIN发生的潜在危险因素。
Objective To investigate whether there is a correlation between H-type hypertension and the occurrence of contrast-induced nephropathy after cardiovascular intervention.Methods A retrospective analysis of the clinical data of 342 patients with essential hypertension who received cardiovascular interventional therapy from May 2020 to August 2021 in Hubei Provincial Hospital of Integrated Traditional Chinese and Western Medicine.According to serum Hcy levels,they were divided into H-type hypertension group(Hcy≥10μmol/L,206 cases in total)and Non-H type hypertension group(Hcy<10μmol/L,136 cases in total).The clinical baseline data and postoperative renal function(Cr,eGFR)and the differences in the incidence of CIN,and logistic regression was used to analyze the risk factors of contrast-induced nephropathy in patients after cardiovascular intervention.Results A total of 24 cases of CIN occurred in 342 patients after cardiovascular intervention,accounting for 7.02%.The incidence of CIN in the H-type hypertension group(9.71%)was higher than that in the Non-H type hypertension group(2.94%),and the difference was statistically significant(P<0.05).After the operation,the Cr of the H-type hypertension group were higher than those of the Non-H type hypertension group,and the eGFR was lower than the Non-H type hypertension group,the difference was statistically significant(P<0.05).Multivariate logistic regression analysis showed that compared with the Non-H type hypertension group,the H-type hypertension group had a significantly increased risk of CIN(OR=1.189,95%CI:1.023~1.383,P=0.024).Conclusion H-type hypertension may be a potential risk factor for CIN after cardiovascular intervention.
作者
赵代鑫
胡晓军
晏凯利
王四坤
郭丽芬
刘恒友
王春明
马军
Zhao Daixin;Hu Xiaojun;Yan Kaili(Department of Internal Medicine-Cardiovascular,Hubei Provincial Hospital of Integrated Chinese and Western Medicine,Wuhan430015,China)
出处
《华北理工大学学报（医学版）》
2023年第2期118-122,共5页
Journal of North China University of Science and Technology：Health Sciences Edition
基金
湖北省卫生健康委员会资助项目(编号:ZY2021M070,WJ2021F118)。
