摘要
[目的]Ni催化偶联关环获得23个2-芳基苯(吡啶)并呋喃类化合物,考察其离体杀菌活性。[方法]通过1H NMR和13C NMR谱确认了目标化合物结构,采用菌丝生长速率法测定了其对茄交链孢、尖孢镰刀菌、灰葡萄孢、链格孢菌4种植物病原真菌抑制活性。[结果]化合物对供试真菌具有不同程度的抑制作用,5l和5s对链格孢的抑制作用显著,处理后96 h抑制率均在94%以上(50 mg/L)。[结论]化合物上取代基R1和R2对抑菌活性有较大影响,吡啶环的引入使得抑菌效果显著提高。
[Aims]232-Aryl benzofuran or furopyridine derivatives were obtained via coupling-cyclization catalyzed with Ni.Their antifungal activities in vitro were investigated.[Methods]The structures of these derivatives were confirmed by~1H NMR and13C NMR.Additionally,their antifungal activities were evaluated by mycelial growth inhibition rate against 4 crop fungi(Alternaria solani,Fusarium oxysporum,Botrytis cinerea and A.alternata).[Results]Most of the compounds showed different degrees of inhibition against the tested fungi.5l and 5s had excellent antifungal activity against A.alternate,with inhibition rate(96 h)above 94%at 50 mg/L.[Conclusions]The activities of the compounds were significantly affected by the groups R1and R2,and greatly enhanced by the introduction of pyridine groups.
作者
李定邦
李鑫
丁彦丽
沙静
李萍
王欢欢
潘乐
金鹿
周蓉
LI Ding-bang;LI Xin;DING Yan-li;SHA Jing;LI Ping;WANG Huan-huan;PAN Le;JIN Lu;ZHOU Rong(College of Chemistry and Chemical Engineering,Xinjiang Agricultural University,Ürümqi 830052,China;International Academy,Guizhou University of Finance and Economics,Guiyang 550000,China)
出处
《农药》
CAS
CSCD
北大核心
2023年第3期163-166,172,共5页
Agrochemicals
基金
国家自然科学基金(21762042)
新疆维吾尔自治区自然科学基金青年科学基金(2016D01B018)。
