摘要
目的:观察复方黄柏液中医外治溻渍法治疗Wagner1~2级糖尿病足溃疡的临床疗效。方法:通过使用随机对照试验设计的方式,将两组患者分为观察组与对照组,每组41例,两组患者在采用常规治疗的基础上分别采用复方黄柏液中医外治溻渍法与纳米银医用抗菌敷料的治疗方式,并观察两组患者治疗前后的溃疡面积、溃疡深度、中医证候评分、踝肱指数、经皮氧分压、血管内皮生长因子、表皮生长因子、晚期糖基化终末产物、超敏C-反应蛋白、白细胞介素-6、红细胞沉降率、不良事件。结果:与本组治疗前比较,两组患者治疗后溃疡面积、溃疡深度、中医证候评分、晚期糖基化终末产物、超敏C-反应蛋白、白细胞介素-6、红细胞沉降率均明显降低(P<0.05),踝肱指数、经皮氧分压、血管内皮生长因子、表皮生长因子均明显升高(P<0.05);治疗后与对照组比较,观察组溃疡面积、溃疡深度、中医证候评分、血管内皮生长因子、表皮生长因子、晚期糖基化终末产物、超敏C-反应蛋白、白细胞介素-6、红细胞沉降率明显降低(P<0.05),踝肱指数、经皮氧分压、血管内皮生长因子、表皮生长因子明显升高(P<0.05);观察组临床疗效优于对照组(χ^(2)=4.561,P<0.05);两组不良事件与终点事件发生差异无统计学意义。结论:复方黄柏液中医外治溻渍法对Wagner1~2级糖尿病足溃疡的治疗有显著效果,有利于促进糖尿病足溃疡的愈合,为复方黄柏液与中药溻渍法的进一步临床推广提供了临床证据。
Objective:To observe the clinical efficacy of compound Huangbai liquid fomentation on diabetic foot ulcer of Wagner grade 1-2.Method:Patients were classified into the observation group and control group,with 41 cases in either group.The observation group received routine therapy and compound Huangbai liquid fomentation,while the control group was treated by routine therapy and medical silver nanoparticlescontaining dressing.Ulcer area,ulcer depth,traditional Chinese medicine(TCM)syndrome score,anklebrachial index,transcutaneous oxygen pressure,vascular endothelial growth factor,epidermal growth factor,advanced glycation end product,high-sensitivity C-reactive protein,interleukin-6,erythrocyte sedimentation rate,and adverse events were observed before and after treatment in two groups.Result:After treatment,the ulcer area,ulcer depth,TCM syndrome score,vascular endothelial growth factor,epidermal growth factor,advanced glycation end product,high-sensitivity C-reactive protein,interleukin-6(IL-6),and erythrocyte sedimentation rate were lower than those before treatment in two groups(P<0.05),and ankle-brachial index,transcutaneous oxygen pressure,vascular endothelial growth factor,and epidermal growth factor were higher than those before treatment in two groups(P<0.05).After treatment,the ulcer area,ulcer depth,TCM syndrome score,advanced glycation end product,high-sensitivity C-reactive protein,IL-6,and erythrocyte sedimentation rate were lower in the observation group than in the control group(P<0.05),and ankle-brachial index,transcutaneous oxygen pressure,vascular endothelial growth factor,and epidermal growth factor were higher in the observation group than in the control group(P<0.05).The clinical efficacy of observation group was better than that of the control group(P<0.05).There was no significant difference in the incidence of adverse events and endpoint events between two groups.Conclusion:Compound Huangbai liquid fomentation is effective for diabetic foot ulcer of Wagner grade 1-2,as it is beneficial to the healing of the ulcer.This study provides clinical evidence for the further promotion of Chinese medicine fomentation.
作者
徐磊
樊炜静
王徐红
柳国斌
XU Lei;FAN Weijing;WANG Xuhong;LIU Guobin(Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200120,China)
出处
《中国实验方剂学杂志》
CAS
CSCD
北大核心
2023年第6期104-110,共7页
Chinese Journal of Experimental Traditional Medical Formulae
基金
国家自然科学基金面上项目(81774310)
国家自然科学基金青年基金项目(81804095)
上海市中医药标准化技术委员会项目(ZYYBZH-202101)
上海中医药大学附属医院“临床研究型骨干人才培养计划”项目(2023LCR06)
浦东新区卫生健康委员会卫生计生科研项目(PW2020E-4)。
关键词
糖尿病足溃疡
Wagner1~2级
复方黄柏液
中药溻渍法
中医外治
diabetic foot ulcer
Wagner grade 1-2
compound Huangbai liquid
Chinese medicine fomentation
external treatment of Chinese medicine
