摘要
目的制备一种以牛至油、荆芥油等复方精油为原料的治疗真菌感染的中药乳膏剂,研究其处方制备工艺,并考察其流变学性质。方法应用流变学参数考察乳膏剂的基质、精油与基质的配比,采用正交试验法优化成型工艺,制备复方中药精油乳膏剂。结果乳膏基质为水包油型,最佳成型工艺参数为剪切速度10 k(r·min^(-1))、剪切时间5 min、两相混合温度65℃,精油加入含量为6%,流变学性质良好。结论该实验制备的乳膏剂性质稳定,抑菌性良好,流变学参数适宜,可进一步开发应用。
Objective To prepare a kind of traditional Chinese medicine cream for the treatment of fungal infection using oregano oil,Schizonepeta oil and other compound essential oil as the raw materials,and to study the preparation process of the prescription,and to investigate its rheological properties.Methods Using the rheological parameters to investigate the matrix of the cream,the ratio of essential oil to the matrix and the molding process parameters were optimized by an orthogonal test.Results The ointment substrate was an oil-in-water type,and the best forming process was as follows:the shear speed was at 10 k(r·min^(-1)),the shear time was at 5 min,and the two-phase mixing temperature was at 65℃,and with the 6%essential oil,the rheological property is good.Conclusion The cream prepared in this study has good quality,good bacteriostatic properties,and excellent rheological parameters,which can be further developed and applied.
作者
韩飞
章静宜
杨辉
梁新丽
董伟
许汉林
杨明
HAN Fei;ZHANG Jingyi;YANG Hui;LIANG Xinli;DONG Wei;XU Hanlin;YANG Ming(College of Pharmacy,Jiangxi University of Traditional Chinese Medicine,Nanchang 330004 China;The Key Laboratory of Modern Chinese Herbal Preparations,Ministry of Education,Jiangxi University of Traditional Chinese Medicine,Jiangxi Nanchang 330004,China;College of Pharmacy,Hubei University of Traditional Chinese Medicine,Wuhan 430065,China)
出处
《医药导报》
CAS
北大核心
2023年第4期536-541,共6页
Herald of Medicine
基金
国家自然科学基金资助项目(81560659,81860771)
江西省教育厅科学技术研究项目(GJJ201219,GJJ2209903)
江西中医药大学博士科研启动基金项目(2018WBZR011)
江西省大学生创新创业训练计划项目(S202110412003,202010412025,202110412028)。
关键词
肤乐乳膏剂
中药精油
制备工艺
流变学
白念珠菌
Fule cream
Chinese medicine essential oil
Preparation process
Rheology
Candida albican
