摘要
目的 研究予以小儿过敏性紫癜清热凉血法治疗的临床价值。方法 便利选择2019年5月—2022年2月在邳州市中医院儿科接受治疗的50例小儿过敏性紫癜患儿为研究对象,采取随机数表法将患儿均分为两组,使用常规西药治疗的25例纳入对照组,基于对照组予以清热凉血法治疗的25例纳入观察组。对比两种治疗措施下的临床效果、症状消失时间、中医症候积分、尿生化指标及炎性因子水平。结果 观察组总有效率为92.00%,高于对照组的68.00%,差异有统计学意义(χ^(2)=4.500,P<0.05)。观察组皮肤紫癜、胃肠道不适、关节症状及蛋白尿转阴症状消失时间为(9.52±2.03)、(8.77±1.03)、(8.59±1.37)、(15.44±2.16)d,均短于对照组的(14.50±1.52)、(12.42±2.65)、(12.56±2.41)、(19.56±3.17)d,差异有统计学意义(t=9.819、6.419、7.160、5.370,P<0.05)。治疗后,观察组中医症候积分为(4.25±1.12)分,低于对照组的(6.32±1.42)分,差异有统计学意义(t=5.723,P<0.05)。观察组TRF、Alb、β-MG水平为(1.42±0.24)、(12.08±4.23)、(0.26±0.06)mg/L,均低于对照组的(2.58±0.20)、(26.40±7.31)、(0.48±0.12)mg/L,差异有统计学意义(t=18.565、8.478、8.199,P<0.05)。观察组IL-8、CRP水平为(19.56±5.12)pg/mL、(9.61±1.82)mg/L,均低于对照组的(30.25±6.54)pg/mL、(12.02±2.65)mg/L,差异有统计学意义(t=6.435、3.748,P<0.05)。结论 予以小儿过敏性紫癜清热凉血法治疗效果显著,能够有助于缩短患儿症状恢复时间,改善尿生化指标,降低患儿机体炎症水平,加快患儿恢复进程,改善预后。
Objective To study the clinical value of being treated with the method of clearing heat and cooling blood in pediatric allergic purpura.Methods Fifty cases of pediatric allergic purpura treated in the pediatric department of Pizhou City Hospital of Traditional Chinese Medicine from May 2019 to February 2022 were conveniently selected as study subjects,and were divided into two groups by random number table method,25 cases treated with conventional western medicine were included in the control group,and 25 cases treated with the method of clearing heat and cool⁃ing blood based on the control group were included in the observation group.The clinical effects,symptom disappear⁃ance time,TCM symptom score,urinary biochemical index and inflammatory factor level under the two treatment mea⁃sures were compared.Results The total effective rate of the observation group was 92.00%,which was higher than 68.00%of the control group,the difference was statistically significant(χ^(2)=4.500,P<0.05).The disappearance time of skin purpura,gastrointestinal discomfort,joint symptoms and proteinuria conversion symptoms in the observation group was(9.52±2.03)d,(8.77±1.03)d,(8.59±1.37)d,(15.44±2.16)d,which were shorter than(14.50±1.52)d,(12.42±2.65)d,(12.56±2.41)d,(19.56±3.17)d in the control group,the difference was statistically significant(t=9.819,6.419,7.160,5.370,P<0.05).After treatment,the TCM symptom score of the observation group was(4.25±1.12)points,which was lower than that of the control group(6.32±1.42)points,the difference was statistically significant(t=5.723,P<0.05).The levels of TRF,Alb,andβ-MG in the observation group were(1.42±0.24)mg/L,(12.08±4.23)mg/L,(0.26±0.06)mg/L,which were lower than(2.58±0.20)mg/L,(26.40±7.31)mg/L,(0.48±0.12)mg/L in the control group,the difference was statistically significant(t=18.565,8.478,8.199,P<0.05).The IL-8 and CRP levels in the observa⁃tion group were(19.56±5.12)pg/mL and(9.61±1.82)mg/L,which were lower than(30.25±6.54)pg/mL and(12.02±2.65)mg/L in the control group,the difference was statistically significant(t=6.435,3.748,P<0.05).Conclusion The treatment of pediatric allergic purpura with the method of clearing heat and cooling blood is effective and can help shorten the recovery time of the child's symptoms,improve urinary biochemical indexes,reduce the level of inflamma⁃tion in the child's organism,speed up the recovery process and improve the prognosis.
作者
柴文芝
刘超
CHAI Wenzhi;LIU Chao(Department of Pediatrics,Pizhou City Hospital of Traditional Chinese Medicine,Pizhou,Jiangsu Province,221300China)
出处
《中外医疗》
2022年第31期181-184,189,共5页
China & Foreign Medical Treatment
关键词
小儿过敏性紫癜
清热凉血法
中医症候积分
Pediatric allergic purpura
Heat-clearing and blood-cooling method
Chinese medicine symptom score
