摘要
目的探讨选用厄贝沙坦、黄葵胶囊联合方案治疗慢性肾炎蛋白尿患者的效果及对其24 h尿蛋白定量水平与炎性因子水平的影响。方法选取2021年3月~2022年3月收治的60例慢性肾炎蛋白尿患者按随机数字表分为两组,给予对照组(30例)患者厄贝沙坦治疗,给予观察组(30例)患者厄贝沙坦+黄葵胶囊治疗,观察患者肾功能相关指标水平、24 h尿蛋白定量及炎性因子水平、β2微球蛋白与不良反应等指标水平变化情况。结果治疗后,观察组患者Scr与BUN水平显著高于对照组,CCr水平显著低于对照组(P<0.05);观察组患者24 h尿蛋白定量水平、IL-6及TNF-α水平较对照组均显著更低(P<0.05);观察组患者β2微球蛋白水平与不良反应总发生率较对照组均显著更低(P<0.05)。结论慢性肾炎蛋白尿患者临床治疗中选用厄贝沙坦、黄葵胶囊联合方案,可明显提高患者炎性因子水平的改善效果,降低24 h尿蛋白定量水平,有效改善其肾功能,获得更理想的治疗有效性。
Objective To investigate the effect of Irbesartan combined with Huangkui Capsule on chronic glomerulonephritis patients with proteinuria and its 24-hour urinary protein and inflammatory factors.Methods Sixty patients with chronic glomerulonephritis and proteinuria admitted to our hospital from March 2021 to March 2022 were randomly divided into two groups and treated with Irbesartan in the control group(30 cases),the patients in the observation group(30 cases)were treated with Irbesartan+Huangkui Capsule,the changes of renal function,24 h urinary protein,inflammatory factors,β2-microglobulin and adverse reactions were observed.Results After treatment,the level of SCR and BUN in the observation group was significantly higher than that in the control group,and the level of CCr was significantly lower than that in the control group(P<0.05).The levels of 24 h urinary protein,IL-6 and TNF-αin the observation group were significantly lower than those in the control group(P<0.05).The level ofβ2-microglobulin and the total incidence of adverse reactions in the observation group were significantly lower than those in the control group(P<0.05).Conclusion The combination of Irbesartan and Huangkui Capsule can significantly improve the level of inflammatory factors and decrease the 24-hour urinary protein level in patients with chronic glomerulonephritis,it can effectively improve the renal function and obtain more ideal therapeutic effectiveness.
作者
崔慧芳
葛俭俭
唐霄杨
CUI Hui-Fang;GE Jian-jian;TANG Xiao-yang(Department of Nephrology,Wujin Hospital Affiliated to Jiangsu University,Wujin Clinical College of Xuzhou Medical University,Changzhou 213000,China)
出处
《中国处方药》
2023年第3期103-106,共4页
Journal of China Prescription Drug
关键词
厄贝沙坦
黄葵胶囊
慢性肾炎
蛋白尿
炎性因子
Irbesartan
Huangkui Capsule
Chronicnephritis
Albuminuria
Inflammatory factor
