摘要
通过多中心横断面研究分析2020年6月1日至2020年9月30日贵州省20家血液透析中心接受维持性血液透析(maintenance hemodialysis,MHD)治疗患者的临床资料,探讨瘦组织指数(lean tissue index,LTI)水平与动静脉内瘘丧失功能(arteriovenous fistula dysfunction,AFD)的相关关系。根据是否发生AFD分为AFD组和非AFD两组,用人体成分分析仪测量LTI。结果发现,2781例MHD患者的AFD发生率为30.0%(835/2781);中位LTI水平为15.2(13.2,17.5)kg/m^(2)。与非AFD组相比,AFD组患者LTI较低(P<0.05)。按LTI三分位数分组中,低LTI组(LTI≤13.9 kg/m^(2))AFD发生率最高(35.5%,334/940),高LTI组(LTI>16.6 kg/m^(2))AFD发生率最低(26.3%,241/916),3组的差异有统计学意义(χ^(2)=20.182,P<0.001)。多因素Logistic回归分析结果显示,中LTI组(13.9 kg/m^(2)<LTI≤16.6 kg/m^(2))和高LTI组发生AFD的风险均低于低LTI组(以低LTI组为参照,OR=0.800,95%CI 0.650~0.986,P=0.036;OR=0.772,95%CI 0.616~0.966,P=0.024)。提示MHD患者低水平LTI与AFD风险增加独立相关。
The clinical data of maintenance hemodialysis(MHD)patients from twenty hemodialysis centers in Guizhou province from June to September 2020 were collected by cross-sectional study.The patients were divided into AFD group and non-AFD group according to whether AFD had occurred.LTI was measured by body composition monitor.The results showed that the incidence of AFD in 2781 MHD patients was 30.0%(835/2781).Median LTI level was 15.2(13.2,17.5)kg/m2.The LTI level in the AFD group was higher than that in the non-AFD group(P<0.05).According to the tertiles of LTI,low LTI group(LTI≤13.9 kg/m2)had the highest incidence of AFD(35.5%,334/940),and the high LTI group had the lowest incidence of AFD(26.3%,241/916),and the difference among the three groups was statistically significant(χ^(2)=20.182,P<0.001).Multivariate logistic regression analysis showed that low LTI group as the reference,the risk of AFD in moderate LTI group(13.9 kg/m^(2)<LTI≤16.6 kg/m^(2))and high LTI group were associated with the 20.0%(OR=0.800,95%CI 0.650-0.986,P=0.036)and 22.8%(OR=0.772,95%CI 0.616-0.966,P=0.024)decrease,respectively.These results suggest that low LTI level is independently associated with an increased risk of AFD in MHD patients.
作者
代露
田茂露
查艳
刘璐
李正胜
黄成宠
袁静
Dai Lu;Tian Maolu;Zha Yan;Liu Lu;Li Zhengsheng;Huang Chengchong;Yuan Jing(Department of Nephrology,the Second Affiliated Hospital of Guizhou University of Traditional Chinese Medicine,Guiyang 550001,China;Department of Nephrology,Guizhou Provincial People's Hospital,Guiyang 550002,China;Key Laboratory of Diagnosis and Treatment of Pulmonary Immune Diseases,NHC,Guiyang 550002,China;Graduate School of Guizhou University of Traditional Chinese Medicine,Guiyang 550002,China)
出处
《中华肾脏病杂志》
CAS
CSCD
北大核心
2023年第1期32-35,共4页
Chinese Journal of Nephrology
基金
贵州省科技厅科技计划(黔科合基础[2019]1194)
贵州省卫生健康委科学技术基金(GZWJKJ 2019-1-107)
贵州省人民医院青年基金(GZSYQN[2021]18)
贵州省肾脏病临床医学研究中心(黔科合平台人才[2020]2201)。
关键词
肾透析
动静脉瘘
危险因素
瘦组织指数
Renal dialysis
Arteriovenous fistula
Risk factors
Lean tissue index
