摘要
目的观察艾滋病HIV/AIDS患者健忘的发生率,并探究其影响因素。方法于2020年6—12月选取河南省农村地区HIV/AIDS患者进行问卷调查,收集患者的信息资料。采用EpiData 3.02录入数据,SPSS 22.0软件进行数据清洗整理,应用χ2检验和多因素Logistic回归进行数据分析。结果共回收问卷1996份,剔除包含缺失值问卷26份和异常值问卷8份,最终得到1962份有效问卷(98.3%),其中发生健忘的HIV/AIDS患者共879例,占比44.8%。单因素分析比较结果显示性别、年龄、婚姻状况、文化程度、职业、HIV感染时间、抗逆转录酶(ART)治疗时间、传播途径以及参与中药治疗等是HIV/AIDS患者发生健忘的影响因素(P<0.05)。多因素Logistic回归分析(逐步向前法)结果显示,女性(OR=1.512,95%CI:1.253~1.825)、HIV感染时间>8年(OR=1.683,95%CI:1.202~2.357)、年龄≥50岁(OR=1.396,95%CI:1.121~1.739)是HIV/AIDS患者发生健忘危险因素;参与中药治疗(OR=0.598,95%CI:0.493~0.726)、职业为非农民(OR=0.670,95%CI:0.462~0.970)是HIV/AIDS患者发生健忘的保护因素(P<0.05)。结论女性、HIV感染时间>8年及年龄≥50岁是HIV/AIDS患者发生健忘的危险因素;参与中医治疗项目及职业为非农民是HIV/AIDS患者发生健忘的保护因素。
Objective To observe the incidence of amnesia in human immunodeficiency virus(HIV)/acquired immune deficiency syndrome(AIDS) patients and explore its influencing factors. Methods From June to December 2020,HIV/AIDS patients in rural areas of Henan Province were selected for a questionnaire survey,and the information of the patients was collected. Epidate 3.02 was used to input data,SPSS 22.0software was used for data cleaning,and χ~2 test and multivariate Logistic regression were used for data analysis.Results A total of 1 996 questionnaires were collected,and 26 questionnaires containing missing values and 8 questionnaires containing outliers were excluded. Finally, 1 962 valid questionnaires(98.3%) were obtained,and 879 HIV/AIDS patients had amnesia,accounting for 44.8%. Univariate analysis showed that gender,age,marital status,education level,occupation,HIV infection time,antiretroviral therapy(ART) treatment time,transmission route and participation in Chinese medicine(CM) treatment were factors infuencing the occurrence of amnesia in HIV/AIDS patients(P<0.05). Multivariate Logistic regression analysis(stepwise forward method)showed that female(OR=1.512,95%CI:1.253~1.825),HIV infection time > 8 years(OR=1.683,95%CI:1.202~2.357),age ≥ 50 years(OR=1.396,95%CI:1.121~1.739) were risk factors for cognitive impairment in HIV/AIDS patients. Participation in CM treatment(OR=0.598,95%CI:0.493~0.726),occupation of non-farmers(OR=0.670,95%CI:0.462~0.970) were protective factors for cognitive impairment in HIV/AIDS patients(P<0.05).Conclusion Female,HIV infection time > 8 years and age ≥ 50 years are risk factors for cognitive impairment in HIV/AIDS patients;participation in CM treatment and occupation as non-farmers are protective factors for amnesia in HIV/AIDS patients.
作者
贾皇超
许前磊
金艳涛
李鹏宇
赵铎
姜琦
朱柯颖
郭会军
JIA Huang-chao;XU Qian-lei;JIN Yan-tao;LI Peng-yu;ZHAO Duo;JIANG Qi;ZHU Ke-ying;and GUO Hui-jun(First Clinical Medical College,Henan University of Traditional Chinese Medicine,Zhengzhou,450003;AIDS Research Center,The First Affiliated Hospital of Henan University of Traditional Chinese Medicine,Zhengzhou,450003)
出处
《中国中西医结合杂志》
CAS
CSCD
北大核心
2023年第2期179-183,共5页
Chinese Journal of Integrated Traditional and Western Medicine
基金
国家自然科学基金资助项目(No.81803953,No.81873289,No.81873187)
中原领军人才项目(No.ZYYCYU202012119)
河南省中医药科学研究专项课题(No.20-21ZY1047,No.2022ZY1032)。
关键词
艾滋病
健忘
影响因素
横断面调查
中药治疗
acquired immune deficiency syndrome
amnesia
influencing factors
ross-sectional survey
Chinese medicinal therapy
