摘要
The classical role of adipocytokines is a negative feedback mechanism,providing information about bodily energy reserves to the brain,and thus controlling satiety and food intake (Campfield et al.,1995).Adipose tissue forms the largest endocrine organ of the body.After the initial description of leptin and its receptor,LEPR/OBR,with its main active isoform OBRb,there was an initial hope for a drugable pathway to counteract the increasing burden of overweight/adiposity,metabolic syndrome,and related disorders (Figure1).
基金
MR is a fellow of the Clinician Scientist Programme (IZKF,University Hospital Erlangen)
Deutsche Forschungsgem einschaft (German Research Foundation
270949263/GRK21 62)
BMBF funded TreatHSP consortium (01GM1905B)。
