摘要
目的 探讨组胺(HA)、可溶性髓样细胞触发受体-1(sTREM-1)、微小核糖核酸-145(miR-145)、超敏C反应蛋白(hs-CRP)在慢性阻塞性肺疾病(COPD)合并冠心病(CHD)患者中的表达特征及检测价值。方法 将107例COPD合并CHD患者设为研究组,同期健康体检者107例设为对照组。抽取受检者血液样本,检测miR-145、HA及sTREM-1、hs-CRP水平。比较2组HA、sTREM-1、miR-145、hs-CRP水平,并比较研究组不同病情严重程度和纽约心脏病协会(NYHA)分级患者的HA、sTREM-1、miR-145、hs-CRP水平。观察各指标水平与病情严重程度、NYHA分级的关联性。结果 研究组HA、sTREM-1、hs-CRP水平高于对照组,miR-145水平低于对照组,差异有统计学意义(P<0.05)。不同COPD病情严重程度患者的HA、sTREM-1、miR-145、hs-CRP水平比较,差异有统计学意义(P<0.05);随着病情严重程度的加剧,HA、sTREM-1、hs-CRP水平持续增高,miR-145持续降低,差异有统计学意义(P<0.05)。不同NYHA分级患者的HA、sTREM-1、miR-145、hs-CRP水平比较,差异有统计学意义(P<0.05);随着NYHA分级的增高,HA、sTREM-1、hs-CRP水平持续增高,miR-145持续降低,差异有统计学意义(P<0.05)。HA、sTREM-1、hs-CRP与COPD病情严重程度、NYHA分级呈正相关,miR-145与COPD病情严重程度、NYHA分级呈负相关(P<0.05)。结论 COPD合并CHD患者的HA、sTREM-1、miR-145、hs-CRP表达异常,且与COPD病情严重程度、NYHA分级密切相关。
Objective To investigate the expression characteristics and detection value of histamine(HA), soluble myeloid cell trigger receptor-1(sTREM-1), microribonuclease-145(miR-145) and hypersensitive C-reactive protein(hs-CRP) in patients with chronic obstructive pulmonary disease(COPD) and coronary heart disease(CHD). Methods A total of 107 healthy people with COPD and CHD were selected as study group, and 107 healthy people with physical examinations in the same period were selected as control group. The blood samples of the subjects were taken to measure the levels of miR-145, HA, sTREM-1 and hs-CRP. The levels of HA, sTREM-1, miR-145 and hs-CRP in the study group and the control group were compared, and their levels in different disease severity and different New York Heart Association(NYHA) grades were compared, and the correlations of the level of each indicator with the disease severity and NYHA grades were observed. Results The levels of HA,s TREM-1 and hs-CRP in the study group were higher than those in the control group,and the level of miR-145 was lower than those in the control group( P < 0. 05). The levels of HA,s TREM-1,miR-145 and hs-CRP in patients with different degrees of COPD showed significant difference,and with increase of the severity of the disease,HA,s TREM-1 and hs-CRP continued to increase,while miR-145 continued to decrease( P < 0. 05). The levels of HA,s TREM-1,miR-145and hs-CRP in different NYHA grades showed significant differences,and with the increase of NYHA grades,HA,s TREM-1 and hs-CRP continued to increase,while miR-145 continued to decrease( P <0. 05). HA,s TREM-1,hs-CRP were positively correlated with the severity of COPD and NYHA grade,while miR-145 was negatively correlated with the severity of COPD and NYHA grade( P <0. 05). Conclusion The expression of HA,s TREM-1,miR-145 and hs-CRP are abnormal in patients with COPD and CHD,which is closely related to the severity of COPD and NYHA grade.
作者
陈艳蓉
刘艳
王珊
张净
CHEN Yanrong;LIU Yan;WANG Shan;ZHANG Jing(Department of Geriatrics,Beijing Friendship Hospital Affiliated to Capital Medical University,Beijing,100050)
出处
《实用临床医药杂志》
CAS
2023年第3期1-5,共5页
Journal of Clinical Medicine in Practice
基金
国家自然科学基金项目(8160050038)。
