摘要
目的分析嘉兴地区无偿献血者人类免疫缺陷病毒(human immunodeficiency virus,HIV)确证阳性的结果,为无偿献血的招募策略和HIV感染防治工作提供参考数据。方法收集嘉兴地区2011~2021年无偿献血者中确证HIV-1抗体阳性的病例,比较各人群分布特征,采用多因素Logistic回归分析探讨嘉兴地区HIV-1抗体阳性人群的特征,并进行蛋白质印迹法条带分析。结果2011~2021年嘉兴地区共检测559331例无偿献血者标本,最终HIV-1抗体确证阳性51例,阳性率为9.12/10万,其中2021年阳性率最低,为1.54/10万。确证HIV-1抗体阳性的无偿献血者的性别、年龄、职业、文化程度、献血频次比较,差异均有统计学意义(P<0.05)。多因素Logistic回归分析结果显示,男性、18~30岁、自由职业和其他、初中文化程度均是感染HIV的主要特征(P<0.05)。HIV-1抗体阳性病例p17、p24、p31、p51、p55、p66、Gp41、Gp120、Gp160全带表达者占比27.45%;Gp160、Gp41、p24三条带100%表达。结论嘉兴地区无偿献血者中检出HIV-1抗体阳性率有下降趋势,在招募无偿献血者时应加强多维度的健康征询,并告知其血源安全的重要性。
Objective To analyse the results of human immunodeficiency virus(HIV)confirmed positive in unpaid blood donors in Jiaxing,and provide reference data for the recruitment strategy of unpaid blood donation and HIV infection prevention and control.Methods The confirmed HIV-1 antibody positive cases among unpaid blood donors in Jiaxing from 2011 to 2021 were collected and the distribution characteristics of different populations were compared.Multiple Logistic regression analysis was used to explore the characteristics of HIV-1 antibody positive population in Jiaxing,and Western blotting strip analysis was performed.Results From 2011 to 2021,a total of 559331 unpaid blood donors were tested in Jiaxing,and 51 cases were confirmed to be HIV-1 antibody positive,with a positive rate of 9.12/100000.The lowest positive rate was 1.54/100000 in 2021.The gender,age,occupation,education level and blood donation frequency of HIV-1 antibody positive unpaid blood donors were statistically significant(P<0.05).The results of multivariate Logistic regression analysis showed that male,18-30 years old,freelance and other,junior high school education were the main characteristics of HIV infection(P<0.05).27.45%of HIV-1 antibody positive patients expressed p17,p24,p31,p51,p55,p66,Gp41,Gp120 and Gp160.Gp160,Gp41 and p24 were 100%expressed.Conclusion The positive rate of HIV-1 antibody detected among unpaid blood donors in Jiaxing showed a decreasing trend.Multidimensional health consultation should be strengthened when recruiting unpaid blood donors,and the importance of blood source safety should be informed.
作者
徐伶莉
倪修文
徐军
XU Lingli;NI Xiuwen;XU Jun(Department of Laboratory,Jiaxing Central Blood Station,Jiaxing 314000,Zhejiang,China)
出处
《中国现代医生》
2023年第7期46-49,共4页
China Modern Doctor
