摘要
目的探究尿微量白蛋白/肌酐比值(ACR)、尿常规与血清肌酐(Scr)联合检测对糖尿病早期肾功能损伤的诊断价值。方法将2021年1月-2022年4月景德镇第一人民医院收治的100例糖尿病伴肾功能损伤患者设为试验组,另取同期体检的100例肾功能正常糖尿病患者为对照组。检测两组ACR、尿常规[尿蛋白(PRO)]与Scr水平并比较。依据尿微量蛋白水平,将试验组分为A组14例(20 mg/L<尿微量蛋白≤50 mg/L)、B组44例(50 mg/L<尿微量蛋白≤300mg/L)、C组23例(300 mg/L<尿微量蛋白≤1000 mg/L)、D组19例(尿微量蛋白>1000 mg/L),分析ACR、尿常规与Scr联合检测对糖尿病早期肾功能损伤的诊断价值。结果试验组ACR、Scr水平高于对照组,且尿常规中PRO阳性率高于对照组(P<0.05);对照组与A组、B组、C组、D组ACR、Scr比较,差异有统计学意义(P<0.05),而尿常规PRO阳性仅出现在B组、C组、D组,A组与对照组的尿常规PRO阳性率比较,差异无统计学意义(P>0.05);ACR、尿常规与Scr联合检测糖尿病早期肾功能损伤的灵敏度(0.835)与特异度(0.712)高于三项单独检测(ACR:灵敏度0.786、特异度0.645;尿常规:灵敏度0.631、特异度0.538;Scr:灵敏度0.724、特异度0.687)(P<0.05)。结论ACR、尿常规与Scr联合检测对糖尿病早期肾功能损伤具有较高诊断价值,有助于糖尿病患者肾损伤的早期识别。
Objective To explore the diagnostic value of combined detection of urinary microalbumin/creatinine ratio(ACR),urine routine and serum creatinine(Scr)in early renal function injury of diabetes.Methods From January 2021 to April 2022,100 patients with diabetes mellitus and renal function injury admitted to Jingdezhen No.1 People's Hospital were set as the text group,and 100 patients with normal renal function were selected as the control group.ACR,urine routine[urine protein(PRO)]and Scr level were detected and compared between the two groups.According to the level of urinary microprotein,the text group was divided into group A(14 cases,20 mg/L<urinary microprotein≤50 mg/L),group B(44 cases,50 mg/L<urinary microprotein≤300 mg/L),group C(23 cases,300 mg/L<urinary microprotein≤1000 mg/L)and group D(19 cases,urinary microprotein>1000 mg/L).The diagnostic value of combined detection of ACR,urine routine and Scr in early renal function injury of diabetes was analyzed.Results The ACR and Scr level of the text group were higher than those of the control group,and the positive rate of PRO in urine routine was higher than that of the control group(P<0.05).There were significant differences in ACR and Scr between the control group and group A,group B,group C and group D(P<0.05),while the positive rate of urine routine PRO only appeared in group B,group C,group D and group A,there was no significant difference in the positive rate of urine routine PRO between the control group and the group B,group C,group D,group A(P>0.05).The sensitivity(0.835)and specificity(0.712)of combined detection of ACR,urine routine and Scr in early renal function injury of diabetes mellitus were higher than those of single detection(ACR:sensitivity 0.786,specificity 0.645;urine routine:sensitivity 0.631,specificity 0.538;Scr:sensitivity 0.724,specificity 0.687)(P<0.05).Conclusion The combined detection of ACR,urine routine and Scr has high diagnostic value for early renal injury in diabetic patients,which is helpful for early identification of renal injury in diabetic patients.
作者
严良烽
陈国艳
夏蕊
YAN Liang-feng;CHEN Guo-yan;XIA Rui(Department of Laboratory,Jingdezhen No.1 People's Hospital,Jingdezhen 333000,Jiangxi,China;Department of Pharmacy,Jingdezhen No.1 People's Hospital,Jingdezhen 333000,Jiangxi,China)
出处
《医学信息》
2023年第7期127-130,共4页
Journal of Medical Information
关键词
糖尿病
早期肾功能损伤
尿微量白蛋白/肌酐比值
血清肌酐
尿常规
Diabetes mellitus
Early renal injury
Urine microalbumin/creatinine ratio
Serum creatinine
Urine routine
