摘要
目的:探究健脾益气汤联合化疗对肺癌术后患者免疫功能的影响。方法:回顾性分析106例肺癌术后患者临床资料,将采用常规化疗的患者纳入对照组(n=53),采用健脾益气汤联合化疗的患者纳入试验组(n=53)。比较两组疗效和治疗前后中医证候积分、免疫功能、生存质量及体重、不良反应。结果:两组患者均顺利完成化疗,试验组治疗总有效率高于对照组(P<0.05);两组治疗后中医证候积分均下降,试验组低于对照组(P<0.05);对照组治疗后CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)水平均下降,CD8^(+)水平上升(P<0.05);试验组CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)水平均上升,CD8^(+)水平下降,试验组CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)、CD8^(+)水平优于对照组(P<0.05);治疗后,两组免疫球蛋白(Ig)A水平比较差异无统计学意义(P>0.05);试验组IgM、IgG水平显著高于对照组(P<0.05);两组治疗后Karnofsky体能状况(KPS)评分、体重均上升,且试验组高于对照组(P<0.05);治疗期间两组恶心呕吐、脱发程度比较差异有统计学意义(P<0.05),肾、肝功能异常程度比较差异无统计学意义(P>0.05)。结论:健脾益气汤联合化疗可改善肺癌术后患者免疫功能,改善患者中医证候和生存质量,改善患者体重,减少化疗药物不良反应,提高疗效。
Objective:To explore the effect of Jianpi Yiqi decoction combined with chemotherapy on immune function in patients with lung cancer after surgery.Methods:A retrospectively was performed on the clinical data of 106 lung cancer patients who had undergone operation.Patients receiving conventional chemotherapy were included in the control group(n=53),and those receiving Jianpi Yiqi decoction combined with chemotherapy were included in the experimental group(n=53).The two groups were compared in terms of curative effect,TCM syndrome scores,immune function,quality of life,weight and adverse reactions.Results:All patients successfully completed chemotherapy.The total effective rate in the experimental group was higher than that in the control group(P<0.05).After treatment,TCM syndrome scores of the two groups decreased,and the scores of the experimental group were lower than those of the control group(P<0.05).After treatment,the levels of T lymphocyte subsets CD3^(+),CD4^(+)and CD4^(+)/CD8^(+)decreased,while CD8^(+)level increased in the control group(P<0.05).After treatment,the levels of CD3^(+),CD4^(+)and CD4^(+)/CD8^(+)increased,while CD8^(+)level decreased in the experimental group,the levels of CD3^(+),CD4^(+),CD4^(+)/CD8^(+)and CD8^(+)in the experimental group were better than those in the control group(P<0.05).After treatment,there was no statistical difference in IgA level between the two groups(P>0.05).After treatment,the experimental group had higher IgM and IgG levels than the control group(P<0.05).After treatment,KPS scores and weight of the two groups increased,and those in the experimental group were higher than the control group(P<0.05).The severity of nausea,vomiting,and alopecia showed statistical difference between groups(P<0.05),but there was no statistical difference in the severity of renal and liver function abnormalities(P>0.05).Conclusion:Jianpi Yiqi decoction combined with chemotherapy can significantly improve immune function,improve TCM syndrome scores and quality of life,increase weight and reduce adverse reactions in patients with lung cancer,and improve efficacy.
作者
李健
贾瑞
王超
丁家宝
高鲲
刘赫
丁玉龙
梁华刚
LI Jian;JIA Rui;WANG Chao;DING Jiabao;GAO Kun;LIU He;DING Yulong;LIANG Huagang(The First Hospital of Qinhuangdao,Qinhuangdao 066099,China)
出处
《陕西中医》
CAS
2023年第4期459-462,共4页
Shaanxi Journal of Traditional Chinese Medicine
基金
河北省秦皇岛市重点研发计划科技支撑项目(202004A103)。
关键词
肺癌
健脾益气汤
培美曲塞
白蛋白紫杉醇
洛铂
免疫功能
Lung cancer
Jianpi Yiqi decoction
Pemetrexed
Albumin paclitaxel
Lobaplatin
Immune function
