摘要
目的探究小儿支气管哮喘急性发作患儿应用小儿平喘方治疗的临床效果及对肺功能的影响。方法选取2020年1月至2021年12月苏州市中西医结合医院的82例小儿支气管哮喘急性发作患儿作为研究对象,采取随机数字表法将其分为对照组(41例)和观察组(41例)。对照组患儿采用布地奈德混悬液治疗,观察组患儿采用布地奈德混悬液^(+)小儿平喘方治疗。比较两组患儿的临床疗效、临床症状评分、肺功能、免疫功能相关指标、血清炎症因子以及不良反应。结果观察组患儿的治疗总有效率高于对照组,差异有统计学意义(P<0.05);观察组患儿治疗后的喘息、咳嗽、哮鸣音等临床症状评分低于对照组,差异有统计学意义(P<0.05);观察组患儿治疗后的第一秒用力呼气容积(FEV1)、一秒率(FEV1/FVC)、最大呼吸流量(PEF)水平高于对照组,差异有统计学意义(P<0.05);观察组患儿治疗后的CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)高于对照组,差异有统计学意义(P<0.05);观察组患儿治疗后的肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)、白介素-8(IL-8)水平低于对照组,差异有统计学意义(P<0.05);观察组患儿的不良反应总发生率低于对照组,差异有统计学意义(P<0.05)。结论小儿支气管哮喘急性发作患儿予小儿平喘方治疗,疗效优良,能够有效改善患儿肺功能,且安全有效,推荐使用。
Objective To investigate the clinical effect of Xiaoer Pingchuan Decoction in children with acute onset of bronchial asthma and its effect on lung function.Methods From January 2020 to December 2021,82 children with acute onset of bronchial asthma in Suzhou Hospital of Integrated Traditional Chinese and Western Medicine were selected as research subjects,and they were divided into control group(41 cases)and observation group(41 cases)by random number table.Children in the control group were treated with Budesonide Suspension,and children in the observation group were treated with Budesonide Suspension^(+)Xiaoer Pingchuan Decoction.The clinical efficacy,clinical symptom score,pulmonary function,immune function-related indicators,serum inflammatory factors and adverse reactions of the two groups were compared.Results The total effective rate of observation group was higher than that of control group,and the difference was statistically significant(P<0.05).The scores of panting,coughing,wheezing and other clinical symptoms in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).The forced expiratory volume in the first second(FEV1),forced expiratory volume in the first second/forced vital capacity(FEV1/FVC)and peak expiratory flow(PEF)in the observation group were higher than those in the control group after treatment,and the differences were statistically significant(P<0.05).The levels of CD3^(+),CD4^(+)and CD4^(+)/CD8^(+)in observation group were higher than those in control group after treatment,and the differences were statistically significant(P<0.05).After treatment,the levels of tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)and interleukin-8(IL-8)in observation group were lower than those in control group,and the differences were statistically significant(P<0.05).The total incidence of adverse reactions in observation group was lower than that in control group,and the difference was statistically significant(P<0.05).Conclusion Children with acute onset of bronchial asthma are treated with Xiaoer Pingchuan Decoction in children,which has excellent efficacy and can effectively improve the lung function of children,and is safe and effective,and is recommended for use.
作者
周玮君
韩月娇
曹芸
ZHOU Weijun;HAN Yuejiao;CAO Yun(Department of Pharmacy,Suzhou Hospital of Integrated Traditional Chinese and Western Medicine,Jiangsu Province,Suzhou215101,China)
出处
《中国当代医药》
CAS
2023年第10期156-160,共5页
China Modern Medicine
关键词
小儿支气管哮喘急性发作
小儿平喘方
临床效果
肺功能
Acute onset of bronchial asthma in children
Xiaoer Pingchuan Decoction
Clinical effect
Lung function
