摘要
强直性脊柱炎是一种累及脊柱和骶髂关节的慢性进行性炎性病变,病情严重及晚期的患者可因广泛关节强直而残疾。目前其发病机制尚未完全明确,临床上也尚缺乏特异性较高的血清学诊断指标。基质金属蛋白酶-3(MMP-3)是针对强直性脊柱炎研究较为深入的血清生物学标志物,通过MMP-3的研究可进一步探讨强直性脊柱炎的早期诊断、病情进展及有效治疗药物。本文综述了血清MMP-3在强直性脊柱炎发生、发展中的作用及其研究进展。
Ankylosing spondylitis(AS)is a chronic and progressive inflammatory disease involving the spine and sacroiliac joints.Patients with severe and advanced AS can be disabled due to extensive ankylosis.However,the pathogenesis of AS is not completely clear,and there is a lack of specific serological diagnostic indexes.Matrix metalloproteinase-3(MMP-3)is an common serum biomarker of AS.The early diagnosis,progression and activity of AS,and effective therapeutic drugs can further explored through the study on the MMP-3.This article reviewed the role of serum MMP-3 in the occurrence and development of AS and its research progress.
作者
范利娟
郝洋
罗亚鸽
马言
李记天
FAN Lijuan;HAO Yang;LUO Yage;MA Yan;LI Jitian(Henan University of Traditional Chinese Medicine,Zhengzhou 450046;Henan Engineering Research Center of Prevention and Treatment of Bone Tumor with Traditional Chinese Medicine,Zhengzhou 450016;Department of Minimally Invasive Spinal Surgery,Henan Luoyang Orthopedic Hospital(Henan Provincial Orthopedic Hospital),Zhengzhou 450016;Guangzhou University of Chinese Medicine,Guangzhou 510006;Key Laboratory of Traditional Chinese Medicine for Basic Research on Bone Tumor,Zhengzhou 450016,China)
出处
《中华骨与关节外科杂志》
CSCD
2023年第1期90-96,共7页
Chinese Journal of Bone and Joint Surgery
基金
青年人才托举工程(2021-QNRC2-A06)
河南省重点研发与推广专项(科技攻关)项目(222102310428)
洛阳市科技发展计划项目(2101043A)。
关键词
强直性脊柱炎
基质金属蛋白酶-3
诊断
进展
应用
Ankylosing Spondylitis
Matrix Metalloproteinase-3
Diagnosis
Progress
Application
