摘要
目的探讨血浆致动脉粥样硬化指数(AIP)对急性胰腺炎(AP)的预测价值。方法回顾性分析2016年1月至2020年12月期间扬州大学附属医院收治的598例AP患者的临床资料,依据亚特兰大分类(2012年修订版)分为重症急性胰腺炎组(SAP组,57例)和非重症急性胰腺炎组(非SAP组,541例)。收集所有入组患者的一般临床资料和相关生化检测指标,并进行急性胰腺炎严重程度床边指数(BISAP)评分、Ranson评分、CT严重程度指数(CTSI)评分。运用logistic回归分析SAP的危险因素。以受试者工作特征(ROC)曲线分析AIP及多种评分系统对胰腺炎严重程度的评估价值。结果SAP组患者的AIP、白细胞(WBC)、中性粒细胞计数(NEUT)、空腹血糖(FBG)、血清总胆固醇(TC)水平、高脂血症占比、糖尿病占比、Ranson评分、BISAP评分、CTSI评分高于非SAP组,差异均有统计学意义(均P<0.05)。多因素logistic回归分析显示AIP为SAP的独立危险因素(P<0.05)。ROC曲线显示,AIP预测SAP的AUC为0.706(95%CI:0.631~0.782,P<0.001)。结论AIP为SAP的独立危险因素,有助于评估AP的严重程度。
Objective To investigate the predictive value of atherogenic index of plasma(AIP)in the assessment of acute pancreatitis(AP).Methods 598 patients diagnosed with AP admitted to the Affiliated Hospital of Yangzhou University between January 2016 and December 2020 were recruited and divided into severe acute pancreatitis group(SAP group,n=57)and non-severe acute pancreatitis group(non SAP group,n=541)according to the Atlanta Classification(2012 revision).General clinical data and related biochemical indicators of all enrolled patients were collected,and Bedside Index of Acute Pancreatitis Severity(BISAP)score,Ranson score and CT Severity Index(CTSI)score were performed.The risk factors of SAP were analyzed by logistic regression.Receiver operating characteristic(ROC)curve was used to analyze the evaluation value of AIP and various scoring systems on the severity of pancreatitis.Results The AIP,white blood cell(WBC),neutrophil count(NEUT),fasting blood glucose(FBG),serum total cholesterol(TC)level,proportion of hyperlipidemia,proportion of diabetes,Ranson score,BISAP score,CTSI score of patients in SAP group were higher than those in non SAP group,and the difference was statistically significant(all P<0.05).Multivariate logistic regression analysis showed that AIP was an independent risk factor for SAP(P<0.05).ROC curve showed that the are under the curve(AUC)of SAP predicted by AIP was 0.706(95%CI:0.631-0.782,P<0.001).Conclusions AIP is an independent risk factor for SAP,which helps to assess the severity of AP.
作者
潘阳
屠夏敏
张俊贤
罗小艳
刘晴谐
李洁
高鑫
路国涛
肖炜明
Pan Yang;Tu Xiamin;Zhang Junxian;Luo Xiaoyan;Liu Qingxie;Li Jie;Gao Xin;Lu Guotao;Xiao Weiming(Pancreatic Center,Department of Gastroenterology,The Affiliated Hospital of Yangzhou University,Yangzhou 225000,China;Yangzhou Key Laboratory of Pancreatic Disease,Yangzhou 225000,China;Dalian Medical University,Dalian 116044,China)
出处
《中国医师杂志》
CAS
2023年第3期360-364,369,共6页
Journal of Chinese Physician
基金
国家自然科学基金(82070668)
扬州市科技计划项目(YZ2021147)。
