摘要
Osteoporosis is a systemic bone disease,which leads to decreased bone mass and an increased risk of fragility fractures.Currently,there are many anti-resorption drugs and osteosynthesis drugs,which are effective in the treatment of osteoporosis,but their usage is limited due to their contraindications and side effects.In regenerative medicine,the unique repair ability of mesenchymal stem cells(MSCs)has been favored by researchers.The exosomes secreted by MSCs have signal transduction and molecular delivery mechanisms,which may have therapeutic effects.In this review,we describe the regulatory effects of MSCs-derived exosomes on osteoclasts,osteoblasts,and bone immunity.We aim to summarize the preclinical studies of exosome therapy in osteoporosis.Furth-ermore,we speculate that exosome therapy can be a future direction to improve bone health.
基金
Supported by National Natural Science Foundation of China,No.81703533
Natural Science Foundation of Shanghai,No.20ZR1449500
Shanghai Jiao Tong University Medical Engineering Cross Fund,No.YG2019GD02
Science Technology Development Fund of Shanghai Pudong New Area,No.PKJ2020-Y28
Medical Discipline Construction Project of Pudong Health Committee of Shanghai,No.PWYts2021-05.
