摘要
目的:观察调胃承气汤联合西药治疗气管插管呼吸机辅助通气患者的效果。方法:选取2018年1月至2021年8月该院行气管插管呼吸机辅助通气的63例患者进行前瞻性研究,按照随机数字表法分为对照组(n=31)和观察组(n=32)。对照组采用常规治疗,观察组在对照组基础上采用调胃承气汤治疗。比较两组呼吸机使用时间、重症监护室(ICU)住院时间、白细胞计数和中性粒细胞计数水平、炎性因子[C反应蛋白(CRP)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)]水平、T细胞亚群指标(CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+))水平及呼吸机相关性肺炎(VAP)发生率。结果:观察组呼吸机使用时间、ICU住院时间均短于对照组,差异有统计学意义(P<0.05);治疗后,两组白细胞计数、中性粒细胞计数和CRP、IL-6、TNF-α水平均低于治疗前,且观察组低于对照组,两组CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)水平均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05);观察组VAP发生率低于对照组,差异有统计学意义(P<0.05)。结论:在常规治疗基础上采用调胃承气汤治疗气管插管呼吸机辅助通气患者可改善T细胞亚群指标水平,缩短呼吸机使用时间和ICU住院时间,降低白细胞计数、中性粒细胞计数、炎性因子水平和VAP发生率,优于单纯常规治疗效果。
Objective:To observe effects of Tiaowei Chengqi decoction on patients with tracheal intubation and ventilator assisted ventilation.Methods:A prospective study was conducted on 63 patients with tracheal intubation and ventilator assisted ventilation in this hospital from January 2018 to August 2021.They were divided into control group(n=31)and observation group(n=32)according to the random number table method.The control group was treated with conventional therapy,while the observation group was treated withT iaowei Chengqi decoction on the basis of that of the control gorup.The ventilator use time,the ICU hospitalization time,the white blood cell count,the neutrophil count,the inflammatory factor levels[C-reactive protein(CRP),interleukin-6(IL-6),and tumor necrosis-α(TNF-α)],the T cell subset levels(CD3^(+),CD4^(+),CD4^(+)/CD8^(+)),and the incidence of ventilator associated pneumonia(VAP)were compared between the two groups.Results:The ventilator use time and the ICU hospitalization tine in the observation group were shorter than those in the control group,and the difference was statistically significant(P<0.05).After the treatment,the white blood cell count,the neutrophil count,and the CRP,IL-6,TNF-αlevels in both groups were lower than those before the treatment,and those in the observation group were lower than those in the control group;the levels of CD3^(+),CD4^(+),CD4^(+)/CD8^(+)in both groups were higher than those before the treatment,and those in the observation group were higher than those in the control group;and the differences were statistically significant(P<0.05).Further,the incidence of VAP in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusions:Tiaowei Chengqi decoction for the patients with tracheal intubation and ventialtor assisted ventilation on the basis of the conventional therapy can improve the levels of T cell subsets,shorten the ventilator use time and the ICU hospitalization time,and reduce the white blood cell count,the neutrophil count,the inflammatory factor levels,and the incidence of VAP.Moreover,it is superior to single conventional therapy.
作者
何海林
黄治明
郭昌文
HE Hailin;HUANG Zhiming;GUO Changwen(Intensive Care Unit of Ruijin Traditional Chinese Medicine Hospital,Ruijin 342500 Jiangxi,China)
出处
《中国民康医学》
2023年第6期113-115,共3页
Medical Journal of Chinese People’s Health
基金
赣州市科技计划指导项目(GZ2020ZSF717)。
关键词
调胃承气汤
呼吸机辅助通气
T细胞亚群
炎性因子
C反应蛋白
呼吸机相关性肺炎
Tiaowei Chengqi decoction
Ventilator assisted ventilation
T cell subset
Inflammatory factor
C-reactive protein
Ventilatorassociated pneumonia
