摘要
目的 研究C反应蛋白(CRP)、甲状腺球蛋白(Tg)、抗甲状腺球蛋白抗体(TgAb)与甲状腺癌患者全切除手术后预后的关系。方法 选取行甲状腺全切除手术的92例甲状腺癌患者,术后收集其病理资料,并检测患者血清CRP、Tg、TgAb水平;采用ROC曲线分析CRP、Tg、TgAb对术后淋巴结转移的预测价值。比较不同血清CRP、Tg、TgAb水平的无进展生存期(PFS)。结果 不同性别、年龄、病理类型、肿瘤直径患者血清CRP、Tg、TgAb水平无统计学意义(P>0.05),淋巴结转移、远处转移患者血清CRP、Tg、TgAb水平高于未转移者(P<0.05)。CRP对患者术后淋巴结转移诊断的AUC为0.720,特异性与敏感度分别为58.3%、80.4%,Tg的AUC为0.784,特异性与敏感度为69.4%、85.7%,TgAb的AUC为0.832,特异性与敏感度为86.1%、83.9%。以ROC曲线的最佳截值点作为临界值,将血清CRP、Tg、TgAb水平分为两组。随访结果显示,CRP≥3.48 mg/L、Tg≥15.93μg/L、TgAb≥34.01 IU/ml的患者PFS低于CRP<3.48 mg/L、Tg<15.93μg/L、TgAb<34.01 IU/ml者(P<0.05)。结论 血清CRP、Tg、TgAb水平在甲状腺全切除手术后淋巴结转移、远处转移患者中较高,对淋巴结转移预测具有一定价值。
Objective To analyze the relationship of C-reactive protein(CRP),thyroglobulin(Tg),anti-thyroglobulin antibody(TgAb)with prognosis of patients with thyroid cancer after total thyroidectomy.Methods 92 patients underwent total thyroidectomy for thyroid cancer were enrolled.Postoperative pathological data were collected,and serum CRP,Tg and TgAb levels were detected.Receiver operating characteristic(ROC)curve was used to evaluate the predictive value of CRP,Tg and TgAb on postoperative lymph node metastasis,and the progression-free survival(PFS)time was compared among patients of different serum CRP,Tg and TgAb levels.Results Serum CRP,Tg and TgAb levels yielded no statistical difference in patients with different gender,age,pathological type and tumor diameter(P>0.05),while the levels of three parameters in patients with lymph node metastasis and distant metastasis were higher than those without metastasis(P<0.05).In predicting the postoperative lymph node metastasis,AUC of CRP was 0.720,with a specificity and sensitivity of 58.3%and 80.4%.The AUC of Tg was 0.784,with a specificity and sensitivity of 69.4%and 85.7%,and the AUC of TgAb was 0.832,with a specificity and sensitivity of 86.1%and 83.9%.With the optimal cut-off points of serum CRP,Tg and TgAb as the critical values,patients were divided into high-and low-groups.Follow-up results showed that patients with CRP≥3.48 mg/L,Tg≥15.93μg/L and TgAb≥34.01 IU/ml had shorter PFS than those with CRP<3.48 mg/L,Tg<15.93μg/L and TgAb<34.01 IU/ml,with statistical difference(P<0.05).Conclusion Serum CRP,Tg and TgAb levels are abnormally elevated in patients with lymph node metastasis and distant metastases after total thyroidectomy,and the three are of great value in predicting lymph node metastasis.
作者
徐曼
刘月
叶亚平
XU Man;LIU Yue;YE Yaping(Nanyang Central Hospital,Nanyang,473000)
出处
《实用癌症杂志》
2023年第4期657-660,共4页
The Practical Journal of Cancer
基金
2019年度河南省医学科技攻关计划联合共建项目(编号:LHGJ20191449)。
