摘要
目的探析平腕立指针刺手法与醒脑解郁汤联合治疗老年抑郁症对其5-羟色胺(5-HT)、去甲肾上腺素(NE)的影响。方法 回顾性分析2021年6月~2022年6月在黑龙江中医药大学附属第一医院就诊的80例老年抑郁症患者临床资料,将采用醒脑解郁汤治疗患者设为对照组(n=40),另将联合醒脑解郁汤与平腕立指针刺手法治疗患者设为试验组(n=40)。比较两组的临床疗效,并观察对比两组治疗前后血清神经递质水平[5-HT、NE、多巴胺(DA)]、汉密尔顿抑郁量表(HAMD)、匹兹堡睡眠质量指数(PSQI)、执行功能评定量表(BRIEF-A)。结果 组间治疗总有效率对比,试验组95.00%高于对照组75.00%(P <0.05)。治疗后,试验组的5-HT、NE、DA水平均较对照组高[(46.52±7.42)pg/ml vs.(40.84±6.88)pg/ml、(565.84±23.58)ng/ml vs.(534.44±22.67)ng/ml、(70.31±7.17)pg/ml vs.(64.77±7.43)pg/ml],HAMD、PSQI、BRIEF-A评分均较对照组低[(7.22±1.12)分vs.(8.04±1.14)分、(7.18±1.29)分vs.(8.46±1.36)分、(97.69±9.88)分vs.(104.33±8.57)分](P <0.05)。结论 对老年抑郁症患者应用平腕立指针刺手法联合醒脑解郁汤治疗,可有效提高其5-HT、NE等神经递质水平,缓解其抑郁症状,改善执行功能,提升其睡眠质量。
Objective To explore the effect of acupuncture technique of flat wrist standing needle and Xingnao Jieyu Decoction on 5-hydroxytrypsin(5-HT)and norepinephrine(NE)in the treatment of senile depression.Methods The clinical data of 80 elderly patients with depression treated in our hospital from June 2021 to June 2022 were retrospectively analyzed.The patients treated with Xingnao Jieyu Decoction were set as the reference group(n=40),and the patients treated with Xingnao Jieyu Decoction combined with the needle prick technique were set as the experimental group(n=40).The clinical efficacy of the two groups was compared,and the levels of serum neurotransmitters[5-HT,NE,dopamine(DA)],Hamilton Depression Scale(HAMD),Pittsburgh Sleep Quality Index(PSQI),Executive Function Rating Scale(BRIEF-A)before and after treatment were observed and compared between the two groups.Results The total effective rate of the experimental group was 95.00%higher than that of the reference group 75.00%(P<0.05).After treatment,The levels of 5-HT,NE and DA in the experimental group were higher than those in the reference group[(46.52±7.42)pg/mL vs.(40.84±6.88)pg/mL、(565.84±23.58)ng/mL vs.(534.44±22.67)ng/mL、(70.31±7.17)pg/mL vs.(64.77±7.43)pg/mL],HAMD,PSQI and brief-A scores were lower than those of the reference group[(7.22±1.12)points vs.(8.04±1.14)points、(7.18±1.29)points vs.(8.46±1.36)points、(97.69±9.88)points vs.(104.33±8.57)points](P<0.05).Conclusions The treatment of elderly patients with depression by using flat wrist needle prick combined with Xingnao Jieyu decoction can effectively improve the levels of neurotransmitters such as 5-HT and NE,relieve their depressive symptoms,improve executive function and improve their sleep quality.
作者
薛剑
刘树民
Xue Jian;Liu Shumin(the Sixth Department of Acupuncture and Moxibustion,the First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine,Harbin 150040,China)
出处
《中华保健医学杂志》
2023年第1期47-50,共4页
Chinese Journal of Health Care and Medicine
基金
2019年度黑龙江中医药大学科研基金项目(2019MS09)。
关键词
老年抑郁症
平腕立指针刺手法
醒脑解郁汤
5-羟色胺
去甲肾上腺素
Senile depression
Flat wrist needle stabbing technique
Xingnao Jieyu decoction
5-hydroxytryptamine
Norepinephrine
