摘要
黄芪是蒙古黄芪[Astragalus membranaceus(Fisch.)Bge.var.mongholicus(Bge.)Hsiao]和膜荚黄芪[Astragalus membranaceus(Fisch.)Bge.]的干燥根,为甘肃大宗药材,其主要化学成分有多糖、黄酮、皂苷、生物碱、氨基酸、微量元素及有机酸等。其药理作用主要集中在提高免疫力、抗氧化、抗肿瘤、保护心血管、促进机体代谢、降血糖、利尿消肿等方面。本文通过文献检索,对黄芪资源分布、化学成分和药理作用进行梳理总结,围绕传统药性、功效、化学成分和不同配伍等方面对黄芪质量标志物(quality marker,Q-Marker)进行了预测分析,最终预测了黄芪多糖、芒柄花苷、毛蕊异黄酮、芒柄花素、黄芪皂苷Ⅰ和Ⅱ、黄芪甲苷等中药成分,为黄芪质量控制提供科学依据。
Huangqi(Astragali Radix)is the dry root of Mongol Milkvetch(Astragalus membranaceus(Fisch.)Bge.var.mongholicus(Bge.)Hsiao)and Membranous Milkvetch(Astragalus membranaceus(Fisch.)Bge.),which is a major medicinal material in Gansu Province.It mainly contains Astragali Radix polysaccharides,flavonoids,saponins,alkaloids,amino acids,trace elements,organic acids and other chemical components.The pharmacological effects of Huangqi mainly focus on improving immunity,anti-oxidation,anti-tumor,protecting cardiovascular,promoting body metabolism,lowering blood sugar,diuresis and decreasing swelling.Based on literature retrieval,the distribution of resources,chemical components and pharmacological effects of Astragalus are reviewed and summarized.The quality markers(Q-Marker)of Astragali Radix are predicted based on traditional medicinal properties,efficacy,chemical components and different compatibility.The chemical components of Astragali Radix polysaccharide,ononin,calycosin,formononetin,astragalosideⅠ,astragalosideⅡ,and astragalosideⅣwere predicted by the analysis,providing a scientific basis for the quality control of Astragali Radix.
作者
张柂儇
刘海龙
王瑞琼
马倩倩
房敏
李泉洋
吴国泰
ZHANG Yi-xuan;LIU Hai-long;WANG Rui-qiong;MA Qian-qian;FANG Min;LI Quan-yang;WU Cuo-tai(Gansu University of Chinese Medicine,Lanzhou 730000,China;Gansu Province Traditional Chinese Medicine Modern Pharmaceutical Engineering Research Institute Co.,Ltd.,Lanzhou 730010,China;Gansu Province Key Laboratory of Pharmacology and Toxicology of Traditional Chinese Medicine,Lanzhou 730000,China)
出处
《中国新药杂志》
CAS
CSCD
北大核心
2023年第4期410-419,共10页
Chinese Journal of New Drugs
基金
甘肃省教育厅双一流学科建设重点科研项目(GSSYLXM-05)
甘肃省2019年重点人才项目(2019-039)。
关键词
黄芪
质量标志物
化学成分
药理作用
免疫调节
Astragali Radix
quality marker
chemical compositions
pharmacological
immunomodulatory
