摘要
目的探讨瑞马唑仑对宫腔镜手术腰硬联合麻醉患者的应用效果。方法选取2021年1月至2022年12月安阳市中医院收治的102例接受宫腔镜手术腰硬联合麻醉患者为研究对象,采用随机数表法分为观察组(51例)和对照组(51例),对照组接受阿芬他尼镇静,观察组接受瑞马唑仑镇静。观察两组患者手术时间、术中出血量及术后疼痛程度(VAS评分),比较两组麻醉诱导前(T_(0))、切开时(T_(1))、手术开始30 min(T_(2))、手术结束时(T_(3))的心率、平均动脉压(MAP),对比两组丙二醛(MDA)、超氧化物歧化酶(SOD)水平。结果两组术后6、24 h的VAS评分比较差异有统计学意义(P<0.05);两组术后24 h的VAS评分低于术后6 h,观察组术后6、24 h的VAS评分均低于对照组(P<0.05)。观察组T_(1)、T_(2)、T_(3)时刻的心率、MAP低于对照组(P<0.05);两组T_(3)时刻的心率、MAP低于T_(0)、T_(1)、T_(2)时刻(P<0.05),两组T_(2)时刻的心率、MAP低于T_(0)、T_(1)时刻(P<0.05),两组T_(1)时刻的心率、MAP低于T_(0)时刻(P<0.05);术后12 h,两组MDA均升高,两组SOD均降低(P<0.05),且观察组MDA低于对照组,SOD高于对照组(P<0.05)。结论瑞马唑仑对宫腔镜手术腰硬联合麻醉患者的镇静效果较好,可发挥镇痛作用,维持血流动力学,减轻氧化应激反应,值得推广与应用。
Objective To investigate the application effects of remazolam in patients undergoing hysteroscopic surgery combined lumbar and epidural anesthesia.Methods A total of 102 patients who received combined lumbar and epidural anesthesia during hysteroscopic surgery in Anyang Hospital of Traditional Chinese Medicine from January 2021 to December 2022 were selected and divided into observation group(51 cases)and control group(51 cases)by random number table method.The control group received afentanil sedation,while the observation group received remidazolam sedation.The operation time,intraoperative blood loss,postoperative pain(VAS score)of two groups were compared.The heart rate and mean artery pressure(MAP)at pre-induction(T_(0)),section time(T_(1)),30 minutes after operation(T_(2))and the end of operation(T_(3))were compared between the two groups,and malondialdehyde(MDA)and superoxide dismutase(SOD)were compared between the two groups.Results There was statistically significant difference in VAS scores between the two groups at 6 and 24 hours after surgery(P<0.05).The VAS scores at 24 hours after surgery in both groups were lower than those at 6 hours,while the VAS scores at 6 and 24 hours after surgery in the observation group were lower than those in the control group(P<0.05).The heart rate and MAP of the observation group at T_(1),T_(2) and T_(3) were lower than those of the control group(P<0.05).The heart rate and MAP of two groups at T_(3) were lower than those of T_(0),T_(1) and T_(2)(P<0.05),while the heart rate and MAP at T_(2) were lower than those of T_(0) and T_(1)(P<0.05).The heart rate and MAP at T_(1) were lower than those of T_(0)(P<0.05).At 12 hours after surgery,both groups had an increase in MDA and a decrease in SOD(P<0.05),and the MDA in the observation group was lower than that in the control group,while SOD was higher than that in the control group(P<0.05).Conclusion Remazolam has a good sedative effect on patients undergoing combined lumbar and epidural anesthesia during hysteroscopic surgery,which is beneficial to play the analgesic effect,maintain hemodynamics and reduce oxidative stress response,and is worthy of popularization and application.
作者
李娜
LI Na(Department of Anesthesiology,Anyang Hospital of Traditional Chinese Medicine,Anyang 455000,China)
出处
《河南医学研究》
CAS
2023年第6期1088-1091,共4页
Henan Medical Research
