摘要
目的:观察重度子宫颈糜烂患者联合应用重组人干扰素α-2b、激光治疗的临床效果。方法:将2021年6月-2022年4月就诊于钟祥市中医院妇科的重度子宫颈糜烂患者80例作为探讨案例,遵循抽签随机分组原则,设为常规组、研究组,各40例。常规组采用单独激光治疗,研究组则在激光治疗同时加用重组人干扰素α-2b。观察两组临床疗效、子宫颈糜烂创面修复时间、外阴瘙痒缓解时间、腹痛缓解时间、阴道血性分泌物消退时间、不良反应,并比较治疗前及治疗4周后炎症细胞因子[C反应蛋白(CRP)、白细胞介素-4(IL-4)、白细胞介素-6(IL-6)、白细胞介素-10(IL-10)],T淋巴细胞[自然杀伤T细胞(NKTs)、调节性T细胞(Tregs)]。结果:研究组患者治疗4周后临床效果较常规组升高,两组比较差异有统计学意义(P<0.05);研究组子宫颈糜烂创面修复时间、外阴瘙痒缓解时间、腹痛缓解时间、阴道血性分泌物消退时间均较常规组缩短,两组比较差异均有统计学意义(P<0.05);治疗4周后,研究组与常规组CRP、IL-4、IL-6均低于治疗前,IL-10、NKTs、Tregs均高于治疗前,且研究组炎症细胞因子及T淋巴细胞表达水平均优于常规组,两组比较差异均有统计学意义(P<0.05);研究组治疗后外阴烧灼感、疼痛、水肿等不良反应发生率低于常规组,但两组比较差异无统计学意义(P>0.05)。结论:对重度子宫颈糜烂患者采用激光联合重组人干扰素α-2b治疗的临床效果更佳,能够有效调节T淋巴细胞,控制临床症状及炎症反应,且不良反应未明显增加,治疗安全可靠。
Objective:To observe the clinical effect of combined treatment with Recombinant Human Interferonα-2b and laser in patients with severe cervical erosion.Method:A total of 80 patients with severe cervical erosion admitted to the Department of Gynecology,Zhongxiang Hospital of Traditional Chinese Medicine from June 2021 to April 2022 were selected as discussion cases.According to the principle of random drawing,they were divided into the conventional group and the study group,with 40 cases in each group.The conventional group was treated with laser alone,while the study group was treated with Recombinant Human Interferonα-2b.The clinical intervention efficacy,repair time of cervical erosion wound,relief time of vulva pruritus,relief time of abdominal pain,regression time of vaginal bloody secretions and adverse reactions were observed in the two groups.Inflammatory cytokines[C reactive protein(CRP),interleukin-4(IL-4),interleukin-6(IL-6),interleukin-10(IL-10)],T lymphocyte[natural killer T cells(NKTs),regulatory T cells(Tregs)]were compared before and 4 weeks after treatment.Result:After 4 weeks of treatment,the clinical effect of patients in the study group was higher than that in the conventional group,the difference between the two groups was statistically significant(P<0.05).The repair time of cervical erosion wound,the relief time of vulva pruritus,the relief time of abdominal pain and the regression time of vaginal bloody secretions in the study group were shorter than those in the conventional group,the differences between the two groups were statistically significant(P<0.05).After 4 weeks of treatment,CRP,IL-4 and IL-6 in the study group and the conventional group were lower than those before treatment,while IL-10,NKTs and Tregs were higher than those before treatment,the expression levels of inflammatory cytokines and T lymphocytes in the study group were higher than those in the conventional group,the differences were statistically significant(P<0.05).After treatment,there was no significant difference between the study group and the conventional group in the rate of vulvar burning,pain,edema and other adverse reactions(P>0.05).Conclusion:Laser combined with Recombinant Human Interferonα-2b in patients with severe cervical erosion has better clinical efficacy,can effectively regulate T lymphocytes,control clinical symptoms and inflammatory reactions,and has no significant increase in adverse reactions,and is safe and reliable.
作者
孙晓雪
SUN Xiaoxue(Zhongxiang Hospital of Traditional Chinese Medicine,Hubei Province,Zhongxiang 431900,China)
出处
《中国医学创新》
CAS
2023年第11期99-103,共5页
Medical Innovation of China
基金
湖北省卫生健康委科技计划项目(20200314)。
