摘要
目的:探讨术前预后营养指数(PNI)、中性粒细胞与淋巴细胞比值(NLR)及血小板与淋巴细胞比值(PLR)对脑胶质瘤患者术后预后的评估价值。方法:回顾性分析2016年2月至2019年2月我院收治的131例脑胶质瘤患者(脑胶质瘤组)的临床资料,另选择同期86例于门诊健康体检的志愿者为对照组,收集相关资料计算PNI、NLR、PLR。比较脑胶质瘤患者不同临床病理特征PNI、NLR、PLR的差异,Kaplan-Meier法绘制不同PNI、NLR、PLR水平脑胶质瘤患者的生存曲线,单因素和多因素COX回归分析影响脑胶质瘤患者预后的相关因素,受试者工作特征曲线(ROC)分析术前PNI、NLR、PLR预测脑胶质瘤患者预后的价值。结果:脑胶质瘤组NLR、PLR高于对照组(P<0.05),PNI低于对照组(P<0.05)。世界卫生组织(WHO)分级Ⅲ级患者NLR、PLR高于WHO分级Ⅰ~Ⅱ级患者(P<0.05),PNI低于WHO分级Ⅰ~Ⅱ级患者(P<0.05)。高NLR组、高PLR组3年生存率低于低NLR组、低PLR组(P<0.05),低PNI组3年生存率低于高PNI组(P<0.05)。WHOⅢ级、NLR(较高)、PLR(较高)是脑胶质瘤患者预后不良的危险因素(P<0.05),PNI(较高)是保护因素(P<0.05)。术前PNI、NLR、PLR联合预测脑胶质瘤患者预后的曲线下面积为0.849,高于单独指标预测的0.703、0.706、0.704。结论:脑胶质瘤患者术前PNI降低,NLR、PLR均升高,且与预后不良有关,术前PNI、NLR、PLR可作为脑胶质瘤患者预后评估的参考指标。
Objective:To investigate the value of preoperative prognostic nutritional index(PNI),neutrophil to lymphocyte ratio(NLR)and platelet to lymphocyte ratio(PLR)in the evaluation of postoperative prognosis in patients with brain glioma.Methods:The clinical data of 131 patients with brain glioma(brain glioma group)who were admitted to our hospital from February 2016 to February 2019 were retrospectively analyzed,and 86 healthy volunteers who underwent physical examination in the outpatient department during the same period were selected as the control group.The relevant data were collected and PNI,NLR and PLR were calculated.The differences of PNI,NLR and PLR in patients with brain glioma with different clinicopathological characteristics were compared.Kaplan-Meier method was used to draw the survival curves of patients with brain glioma with different levels of PNI,NLR and PLR.Univariate and multivariate COX regression analysis was used to analyze the related factors affecting the prognosis of patients with brain glioma.Receiver operating characteristic curve(ROC)was used to analyze the value of preoperative PNI,NLR and PLR in predicting the prognosis of patients with brain glioma.Results:The NLR and PLR in the brain glioma group were higher than those in the control group(P<0.05),and PNI was lower than that in the control group(P<0.05).The NLR and PLR of patients with World Health Organization(WHO)grade II were higher than those of patients with WHO grade I~II(P<0.05),and the PNI was lower than that of patients with WHO grade I~II(P<0.05).The 3-year survival rate of high NLR group and high PLR group were lower than those of low NLR group and low PLR group(P<0.05),and the 3-year survival rate of low PNI group was lower than that of high PNI group(P<0.05).WHO grade II,NLR(higher)and PLR(higher)were risk factors for poor prognosis in patients with brain glioma(P<0.05),and PNI(higher)was a protective factor(P<0.05).The area under curve of preoperative PNI,NLR and PLR combined to predict the prognosis of patients with brain glioma was 0.849,which was higher than the prediction of 0.703,0.706 and 0.704 by single indicator.Conclusion:Preoperative PNI is decreased,NLR and PLR are increased in patients with brain glioma,which are related to poor prognosis.Preoperative PNI,NLR and PLR can be used as reference indicators for prognosis assessment of patients with brain glioma.
作者
陈莉莉
李鑫
康晓慧
秦玥
魏文艳
CHEN Li-li;LI Xin;KANG Xiao-hui;QIN Yue;WEI Wen-yan(International Department of Beijing Tiantan Hospital Affiliated to Capital Medical University,Beijing,100070,China)
出处
《现代生物医学进展》
CAS
2023年第5期845-849,共5页
Progress in Modern Biomedicine
基金
首都医科大学附属北京天坛医院青年科研基金项目(2021-YQN-09)
北京市自然科学基金资助项目(7182049)。
