摘要
孤立性远端深静脉血栓是下肢深静脉血栓的一个亚型,常因其症状隐匿未引起足够的重视,但仍存在发展为近端深静脉血栓和肺栓塞的风险。针对孤立性远端深静脉血栓是否需要抗凝治疗、抗凝药物剂量以及抗凝疗程国内外尚未达成共识。本文通过系统性文献回顾,从流行病学、危险因素、抗凝治疗等方面对孤立性远端深静脉血栓进行归纳,根据相关指南推荐,对于有严重症状和额外危险因素的孤立性远端深静脉血栓患者,首选抗凝治疗,优先选择治疗剂量的新型口服抗凝药,抗凝时间保持至少3个月,但推荐级别不高。目前仍然缺乏大型随机对照试验论证抗凝治疗的获益与风险,仍需更多的临床试验数据支持。
Isolated distal deep vein thrombosis(IDDVT)is a subtype of deep vein thrombosis of lower extremities,which has not attracted enough attention due to its hidden symptoms,but it still has the risk of developing into proximal deep vein thrombosis and pulmonary embolism.As for whether IDDVT requires anticoagulant therapy,anticoagulant drug dosage,and the course of anticoagulant therapy,no consensus has been reached at home and abroad.In this paper,the epidemiology,risk factors,anticoagulant therapy and other aspects were summarized.For IDDVT patients with severe symptoms and additional risk factors,anticoagulant therapy is the first choice,and new oral anticoagulants at therapeutic dosages are preferred.The anticoagulant time should be maintained for at least 3 months,which can reduce the risk of thrombosis recurrence.There is still a lack of large randomized controlled trails to demonstrate the benefits and risks of anticoagulant therapy,and more clinical trial data are needed to support it.
作者
王晴
王宝彦
季润
王宜梅
乔彤
WANG Qing;WANG Bao-yan;JI Run;WANG Yi-mei;QIAO Tong(Department of Vascular Surgery,Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine,Nanjing 210031,China;Department of Pharmacy,Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University,Nanjing 210031,China;Department of Vascular Surgery,Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University,Nanjing 210031,China)
出处
《临床药物治疗杂志》
2023年第3期7-11,共5页
Clinical Medication Journal
基金
国家自然科学基金(81900427)
南京鼓楼医院临床研究专项资金项目(2021-LCYJ-PY-19)。
关键词
孤立性远端深静脉血栓
抗凝治疗
抗凝药物剂量
抗凝疗程
isolated distal deep vein thrombosis
anticoagulant therapyi anticoagulant dose
the course of anticoagulant therapy
