摘要
目的观察加味三黄石膏汤对痰热壅肺型支气管扩张症患者的临床疗效、肺功能及炎症因子的影响。方法将90例痰热壅肺型支气管扩张症急性期患者随机分为中药组和西药组,每组各45例。西药组予左氧氟沙星片口服,每次0.5 g,每日1次;中药组予加味三黄石膏汤口服,每日1剂,分2次服用。两组疗程均为14 d。比较治疗前后两组的中医证候积分、生活质量评分、炎性因子水平、外周血炎性指标、肺功能及安全性指标情况,并评价临床疗效。结果中药组总有效率(95.56%,43/45)明显高于西药组(82.22%,37/45)(P<0.05);治疗后两组的中医证候积分、白细胞计数(white blood cell count,WBC)、超敏C反应蛋白(high sensitivity C-reactive protein,hs-CRP)、血清白介素6(interleukin 6,IL-6)、白三烯B4(leukotriene-B4,LT-B4)及肿瘤坏死因子α(tumor necrosis factor,TNF-α)水平均较治疗前下降(P<0.05);治疗后两组的生活质量评分均较治疗前升高(P<0.05);中药组肺功能异常患者在治疗后肺功能显著改善(P<0.05);中药组治疗后的中医证候积分、IL-6及LT-B4水平更低(P<0.05)。结论加味三黄石膏汤治疗痰热壅肺型支气管扩张症疗效更佳,既能有效缓解临床症状、提升肺功能及生活质量,又能下调炎性因子水平、减轻炎性反应、调节免疫功能,且未见明显不良反应,值得推广应用。
Objective To observe the effects of Modified Sanhuang Shigao Decoction(加味三黄石膏汤)on clinical efficacy,lung function and inflammatory factors in patients with phlegm-heat obstructing lung syndrome.Methods A total of 90 patients of bronchiectasis with phlegm-heat obstructing lung syndrome were randomly divided into traditional Chinese medicine(TCM)group and western medicine group,with 45 cases in each group.The western medicine group was given levofloxacin tablets oral⁃ly,0.5 g for each time,once a day.And the TCM group was given Modified Sanhuang Shigao Decoction orally,one dose a day,twice a day.Both groups were treated for 2 weeks.The TCM syndrome scores,quality of life scores,levels of inflammatory fac⁃tors,white blood cell count(WBC),high sensitivity C-reactive protein(hs-CRP),inflammatory factors,lung function and safety indicators were compared between the two groups before and after treatment,and the clinical efficacy was evaluated.Results The total effective rate of the TCM group(95.56%,43/45)was significantly higher than that of the western medicine group(82.22%,37/45)(P<0.05).After treatment,the TCM syndrome score,the levels of WBC,hs-CRP,interleukin 6(IL-6),leukotriene-B4(LT-B4)and tumor necrosis factorα(TNF-α)in two groups were decreased compared with those before treatment(P<0.05).After treatment,the quality of life scores of both groups were higher than those before treatment(P<0.05).The patients with abnormal lung function in the TCM group were significantly improved after treatment(P<0.05).The TCM syndrome score,the levels of IL-6 and LT-B4 in the TCM group were lower after treatment(P<0.05).Conclusion Modi⁃fied Sanhuang Shigao Decoction has a significant therapeutic effect on the acute bronchiectasis patients with phlegm-heat ob⁃structing lung syndrome,which can not only effectively alleviate clinical symptoms,improve lung function and quality of life,but also reduce the level of inflammatory factors,reduce inflammatory response and regulate immune function,and no obvious adverse reactions are observed,and so it is worthy of promotion and application.
作者
洪波
孙鸣欢
胡旭贞
鮑翊君
沈洁如
陈玲
周晶晶
HONG Bo;SUN Minghuan;HU Xuzhen;BAO Yijun;SHEN Jieru;CHEN Ling;ZHOU Jingjing(Ningbo Hospital of Traditional Chinese Medicine,Ningbo 315010,Zhejiang,China)
出处
《中华中医药学刊》
CAS
北大核心
2023年第2期181-184,共4页
Chinese Archives of Traditional Chinese Medicine
基金
浙江省中医药科技计划项目(2017ZA127)。
关键词
加味三黄石膏汤
支气管扩张症
痰热壅肺型
肺功能
炎性因子
Modified Sanhuang Shigao Decoction(加味三黄石膏汤)
bronchiectasis
phlegm-heat obstructing lung syn⁃drome
lung function
inflammatory factor
