摘要
中药的生物靶点是中药和机体互作的核心元件,明确中药靶点对阐明中药的物质基础和作用机制至关重要。通过对中药和靶点的作用方式进行总结和定义,系统阐述了当前中药靶点研究发现的思路和方法,评述其特点和缺陷,在此基础上,将几种思路凝练整合,提出一种“基于整体化学和生物效应谱推演的中药靶点研究新模式”,综合“化学性”和“生物性”对中药靶点作用路径进行系统研究,并对新模式在中医药领域的应用进行总结,为中药分子作用机制研究提供更加系统的思路和框架。
The biological targets of traditional Chinese medicine(TCM)are the core effectors mediating the interaction between TCM and human body.Clarifying targets of TCM is very important to elucidate material basis and action mechanism of TCM.By summarizing and defining the modes of action of TCM and targets,this paper systematically expounds the current thinking and methods of TCM target research,and summarize characteristics and defects of these methods.On this basis,this study integrates these methods,and propose a novel target identification model based on TCM overall chemical and biological profiles.This model can systematically explore the action path of TCM and targets from both“chemical”and“biological”information.The applications of model in field of TCM are summarized and further illustrated with specific cases.We expect that this novel model could provide a more systematic framework for study of molecular mechanisms of TCM.
作者
李鹏
张浩然
张元媛
詹灵敏
陈建新
LI Peng;ZHANG Hao-ran;ZHANG Yuan-yuan;ZHAN Ling-min;CHEN Jian-xin(Shanxi Key Laboratory for Modernization of Traditional Chinese Veterinary Medicine,College of Basic Sciences,Shanxi Agricultural University,Taigu 030801,China;School of Traditional Chinese Medicine,Beijing University of Chinese Medicine,Beijing 100029,China)
出处
《中草药》
CAS
CSCD
北大核心
2023年第6期1986-1997,共12页
Chinese Traditional and Herbal Drugs
基金
国家自然科学基金面上项目(82274363)
国家自然科学基金青年项目(81703945)
山西省基础研究计划面上项目(20210302124129)。
关键词
新方法
中药靶点
转录组
中药成分
药物靶标预测
生物性
化学性
new methods
TCM targets
transcriptomics
TCM ingredients
drug-target prediction
biological property
chemical property
