摘要
Hydrogels are emerging as the most promising dressings due to their excellent biocompatibility,extracellular matrix mimicking structure,and drug loading ability.However,existing hydrogel dressings exhibit limited breathability,poor environmental adaptability,potential drug resistance,and limited drug options,which extremely restrict their therapeutic effect and working scenarios.Here,the current research introduces the first paradigm of hydrogel textile dressings based on novel gelatin glycerin hydrogel(glyhydrogel)fibers fabricated by the Hofmeister effect based wet spinning.Benefiting from the unique knitted structure,the textile dressing features excellent breathability(1800 times that of the commercially available 3 M dressing)and stretchability(535.51±38.66%).Furthermore,the glyhydrogel textile dressing can also withstand the extreme temperature of-80℃,showing the potential for application in subzero environments.Moreover,the introduction of glycerin endows the textile dressing with remarkable antibacterial property and expands the selection of loaded drugs(e.g.,clindamycin).The prepared glyhydrogel textile dressing shows an excellent infected wound healing effect with a complete rat skin closure within 14 days.All these functions have not been achievable by traditional hydrogel dressings and provide a new approach for the development of hydrogel dressings.
基金
National Key Research and Development Program of China(2021YFC2101800,2021YFC2400802)
National Natural Science Foundation of China(52173117)
Natural Science Foundation of Shanghai(20ZR1402500)
Belt&Road Young Scientist Exchanges Project of Science and Technology Commission Foundation of Shanghai(20520741000)
Ningbo 2025 Science and Technology Major Project(2019B10068)
Science and Technology Commission of Shanghai Municipality(20DZ2254900,20DZ2270800)
Fundamental Research Funds for the Central Universities,DHU Distinguished Young Professor Program(LZA2019001)
Shanghai Stomatological Hospital Science and Technology Talents Project(SSH-2022-KJCX-B01).
