摘要
目的观察清肝化痰方治疗高血压前期(prehypertension,PHT)的临床疗效。方法招募健康体检人群中PHT(BP:120~139 mm Hg/80~89 mm Hg)受试者60例。以随机数字表法分为观察组及对照组各30例,对照组实际观察27例(3例脱落),给予健康宣教,引导改善生活方式;观察组实际观察28例(2例脱落),在对照组基础上给予清肝化痰方治疗。共治疗4周,并以治疗前后的诊室血压、中医证候量表及动脉粥样硬化性心血管疾病(atherosclerotic cardiovascular disease,ASCVD)发病风险预测模型(China-PAR)进行疗效评价。结果与干预前相比,干预后两组受试者的中医证候积分、收缩压(systolic blood pressure,SBP)水平及观察组的舒张压(diastolic blood pressure,DBP)水平、ASCVD十年风险与终身风险均有降低(P<0.01,P<0.05);观察组干预后的中医证候积分、SBP、DBP及ASCVD十年风险均低于对照组(P<0.01,P<0.05)。观察组血压值疗效及中医证候积分疗效分别为64.29%和82.14%,对照组分别为22.22%和37.03%,观察组总体疗效水平明显优于对照组(P<0.01)。从具体症状上看,两组急躁易怒、头重如裹、胸闷、畏寒肢冷、口淡、口干、失眠、气短症状均有改善(P<0.05)。此外,观察组受试者的眩晕、头痛、呕吐痰涎、面赤、口苦、耳鸣症状也有改善(P<0.01,P<0.05),且观察组的眩晕、急躁易怒、呕吐痰涎、面赤、口干、口苦、心悸、耳鸣症状改善程度较对照组差异有统计学意义(P<0.05)。结论清肝化痰方治疗PHT相较于单纯生活方式干预降压效果更显著,且能安全有效地改善临床症状并降低罹患ASCVD的风险。
Objective To observe the clinical effect of Qinggan Huatan Decoction(清肝化痰方)in the treatment of prehypertension(prehypertension,PHT).Methods 60 people with PHT(BP:120-139 mm Hg and/or 80-89 mm Hg)in the healthy physical examination population were recruited.Divided into the observation group and the control group by random number table method,30 people in each group.In the control group,27 cases(3 cases dropped out)were actually observed,and they were given health education and guidance to improve their lifestyles.In the observation group,28 cases were actually observed(2 cases fell off),and on the basis of the control group,Qinggan Huatan Decoction was given.A total of 4 weeks of treatment were used to evaluate the efficacy of the clinic blood pressure,TCM syndrome scale and atherosclerotic cardiovascular disease(ASCVD)risk prediction model(China-PAR)before and after treatment.Results Compared with before the intervention,the TCM syndrome scores,systolic blood pressure(SBP)levels in the two groups,and the diastolic blood pressure(DBP)levels as well as the tenyear risk and lifetime risk of ASCVD of the observation group,after the intervention was reduced(P<0.01,P<0.05);the TCM syndrome score,SBP,DBP and ASCVD ten-year risk in the observation group after intervention were lower than those in the control group(P<0.01,P<0.05).The curative effect of blood pressure value and TCM symptom score were 64.29%and 82.14%in the observation group,respectively,and 22.22%and 37.03%in the control group.The overall curative effect of the observation group was significantly better than that of the control group(P<0.01).In terms of specific symptoms,the symptoms of irritability,heaviness in the head,chest tightness,chills and cold limbs,light mouth,dry mouth,insomnia,and shortness of breath were improved in both groups(P<0.05).In addition,the symptoms of dizziness,headache,vomiting,sputum,red face,bitter mouth,and tinnitus were also improved in the observation group(P<0.01,P<0.05).Compared with the control group,the symptoms of flushing,dry mouth,bitter mouth,palpitations and tinnitus were significantly improved(P<0.05).Conclusion Qinggan Huatan Decoction has more significant antihypertensive effect than simple lifestyle intervention in the treatment of prehypertension,and can safely and effectively improve clinical symptoms and reduce the risk of ASCVD.
作者
张裕
赵瑞珍
马迪
陈婧
崔民英
扈琨
张东枢
李江林
荆鲁
ZHANG Yu;ZHAO Ruizhen;MA Di;CHEN Jing;CUI Minying;HU Kun;ZHANG Dongshu;LI Jianglin;JING Lu(Beijing University of Chinese Medicine,Beijing 100029,China;The Third Affiliated Hospital of Beijing University of Chinese Medicine,Beijing 100029,China;Eye Hospital of China Academy of Chinese Medical Sciences,Beijing 100040,China)
出处
《辽宁中医药大学学报》
CAS
2023年第3期187-191,共5页
Journal of Liaoning University of Traditional Chinese Medicine
基金
国家重点研发计划项目(2019YFC1710101)。
关键词
高血压前期
清肝化痰方
疗效评价
prehypertension
Qinggan Huatan Decoction(清肝化痰方)
efficacy evaluation
