摘要
目的:观察滋阴止咳方加减联合丙酸氟替卡松吸入气雾剂治疗小儿慢性咳嗽的疗效。方法:选取62例慢性咳嗽阴虚肺热证患儿,按随机数字表法分为2组各31例。对照组采用丙酸氟替卡松吸入气雾剂治疗,治疗组在对照组基础上联合滋阴止咳方加减治疗。2组均治疗1个月。比较2组的临床疗效及不良反应发生率,比较2组治疗前后的血清免疫球蛋白E(IgE)水平、嗜酸性粒细胞计数(EOS)值、中医证候积分、肺功能指标[第1秒用力呼气容积(FEV_(1))、最大呼气流量(PEF)、用力肺活量(FVC)、FEV_(1)/FVC]。结果:治疗后,治疗组临床疗效总有效率为96.77%,高于对照组(77.42%)(P<0.05)。2组IgE水平、EOS值及中医证候积分均较治疗前下降(P<0.05),治疗组上述3项指标值均低于对照组(P<0.05)。2组FEV_(1)、PEF、FVC水平及FEV_(1)/FVC值均较治疗前升高,治疗组上述4项指标值均高于对照组(P<0.05)。对照组不良反应发生率与治疗组比较,差异无统计学意义(P>0.05)。结论:滋阴止咳方加减联合丙酸氟替卡松吸入气雾剂治疗小儿慢性咳嗽疗效较好,能提高患儿的免疫功能及肺功能,缓解临床症状。
Objective:To observe the curative effect of the therapy of modified Ziyin Zhike Prescription combined with Fluticasone Propionate Inhalation on children with chronic cough. Methods : A total of62 children with chronic cough with Yin deficiency and lung heat syndrome were selected and divided into the treatment group and the control group according to random number table method,with 31 cases in each group. The control group was treated with Fluticasone Propionate Inhalation,and the treatment group was additionally treated with modified Ziyin Zhike Prescription based on the treatment of the control group.The clinical effects and incidence of adverse reactions were compared between the two groups. The changes in serum levels of immunoglobulin E(IgE),the levels of eosinophil count(EOS),the total scores of traditional Chinese medicine(TCM) syndromes and the levels of lung function indexes,including forced expiratory volume in one second(FEV_(1)),peak expiratory flow(PEF),forced vital capacity(FVC) and FEV_(1)/FVC were compared before and after treatment between the two groups. Results:The total effective rate was 77.42% in the control group,which was lower than that in the treatment group 96.77%(P<0.05). After treatment, the IgE and EOS levels and the total scores of TCM syndromes in the two groups were decreased when compared with those before treatment(P<0.05);the above 3 indexes in the treatment group were lower when compared with control group(P<0.05). After treatment,the levels of FEV_(1),PEF,FVC and FEV_(1)/FVC in the two groups were increased when compared with those before treatment(P<0.05),and the levels of above 4 indexes in the treatment group were higher than those in the control group(P<0.05). The incidence of side reactions was no significant difference between the control group and the treatment group(P>0.05). Conclusion: The therapy of modified Ziyin Zhike Prescription combined with Fluticasone Propionate Inhalation can improve the immune function and lung function,and relieve clinical symptoms of children with chronic cough.
出处
《新中医》
CAS
2023年第6期93-96,共4页
New Chinese Medicine
关键词
慢性咳嗽
儿童
阴虚肺热证
滋阴止咳方
肺功能
Chronic cough
Children
Yin deficiency and lung heat syndrome
Ziyin Zhike Prescription
Lung function
