摘要
目的观察盐酸右美托咪定经口给药对椎管内麻醉患者的镇静效果。方法选择锦州市中心医院拟行硬脊联合麻醉患者[美国麻醉师协会(ASA)分级Ⅱ级]60例,采用随机数表法将患者均分为对照组(A组)、右美托咪定雾化吸入组(B组)及右美托咪定口腔喷雾组(C组),每组20例。记录三组患者入室(T0)、麻醉后(T1)给予右美托咪定后10 min(T2)、20 min(T3)及30 min(T4)的镇静评分及心率变化,同时记录硬脊联合麻醉患者给药后的入睡时间,记录各组患者心动过缓、低血压等不良反应发生率。结果A组与B组患者在各时间点的心率及镇静评分比较,差异无统计学意义(P>0.05);与A、B两组比较,C组患者在T3时刻心率出现明显降低,镇静评分增加(P<0.05);C组T3与TO、T1时刻比较,心率降低,镇静评分增高,差异有统计学意义(P<0.05),与T4时刻心率及镇静评分比较,差异无统计学意义(P>0.05)。其中,C组患者在给药后可进入睡眠状态,入睡时间为给药后(60.15±7.66)min。三组患者中仅C组出现2例短时间呛咳,其余患者均未观察到不良反应。结论盐酸右美托咪定1.5μg/kg经口腔颊黏膜喷雾的给药方式可取得较好的镇静效果。
Objective To observe the sedative effect of dexmedetomidine hydrochloride on patients under spinal anesthesia.Methods A total of 60 patients[The American Society of Anesthesiologists(ASA)is graded Ⅱ]were selected from Jinzhou Central Hospital.Using random number table method,the patients were divided into 3 groups(n=20):control group(group A),dexmedetomidine atomization inhalation group(group B)and dexmedetomidine oral spray group(C group).The sedation scores and heart rate changes of patients entering the room(TO)and after anesthesia(T1)after dexmedetomidine administration were recorded at 10 minutes(T2),20 minutes(T3)and 30 minutes(T4),and the time to sleep after administration in patients with scleropractic combined anesthesia is recorded.The incidence of adverse reactions such as bradycardia and hypotension in each group were recorded.Results Compared with group A,there was no significant difference in the changes of heart rate and sedation score in group B at each time point(P>0.05).with TO and T1 in group C,the heart rate decreased and the sedation score increased,with a statistically significant difference(P<0.05),but there was no significant difference compared with T4(P>0.05).Among them,patients in group C could enter sleep state after administration,and the time to fall asleep was(60.15±7.66)min after administration.Among the three groups of patients,only 2 cases of short-term choking occurred in group C,and no adverse reactions were observed in other patients.Conclusion Compared with the control group,there was no significant change in the administration mode of dexmedetomidine hydrochloride 1.5 μg/kg through oral atomization.The administration mode of dexmedetomidine hydrochloride through buccal mucosa spray could produce better sedative effect.
作者
李牧
杨森
LI Mu;YANG Sen(Graduate Training Base,Jinzhou Central Hospital,Jinzhou Medical University Jinzhou Liaoning 121000,China;Department of Anesthesiology,Jinzhou Central Hospital,Jinzhou Liaoning 121000,China)
出处
《中华养生保健》
2023年第9期26-29,共4页
CHINESE HEALTH CARE
关键词
盐酸右美托咪定
镇静评分
经口给药
dexmedetomidine hydrochloride
sedation score
oral administration
