摘要
目的探讨循十二经之井穴针刺配合西医治疗癫痫的效果及对血清学指标的影响。方法选取2020年9月—2022年1月160例癫痫为研究对象,按照治疗方法不同分为联合组和西医组,每组80例。联合组给予循十二经之井穴针刺配合西医治疗,西医组给予西医治疗。比较2组总有效率、癫痫发作频率、发作持续时间、血脂指标[三酰甘油(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)]、炎性指标[高迁移率族蛋白B1(HMGB1)、白细胞介素-6(IL-6)、核因子-κB(NF-κB)、IL-10]及不良反应情况。结果联合组总有效率高于西医组(P<0.05)。治疗后,2组癫痫发作频率、发作持续时间均较治疗前降低或缩短,且联合组低于或短于西医组(P<0.05)。治疗后,2组TG、TC、HDL-C、LDL-C水平比较差异均无统计学意义(P>0.05)。治疗后,2组HMGB1、IL-6、NF-κB、IL-10水平均低于治疗前,且联合组低于西医组(P<0.05)。2组不良反应发生率比较差异无统计学意义(P>0.05)。结论循十二经之井穴针刺配合西医抗癫痫治疗,能改善患者癫痫发作情况,增强疗效,抑制炎症反应,且不影响血脂代谢,具有一定安全性。
Objective To investigate the effect of acupuncture at well points along the twelve meridians combined with western medicine in the treatment of epilepsy and its impact on serological indexes.Methods A total of 160 patients with epilepsy from September 2020 to January 2022 were selected as the research subjects and divided into a combination group(n=80)and a Western medicine group(n=80)according to different treatment methods.The combination group was given acupuncture at the well point following the twelve meridians combined with Western medicine treatment,and the Western medicine group was given Western medicine.The total effective rate,seizure frequency,seizure duration,lipid indexes[triacylglycerol(TG),total cholesterol(TC),high-density lipoprotein cholesterol(HDL-C),and low-density lipoprotein cholesterol(LDL-C)],inflammatory indexes[high mobility group box protein B1(HMGB1),interleukin-6(IL-6),nuclear transcription factor-κB(NF-κB),interleukin-10(IL-10)]and adverse reactions were compared between the two groups.Results The total effective rate of the combination group was higher than that of the Western medicine group(P<0.05).After treatment,the frequency and duration of seizures in both groups were lower or shorter than those before treatment,and lower or shorter in the combination group than in the Western medicine group(P<0.05).After treatment,there was no statistically significant difference in the levels of TG,TC,HDL-C,and LDL-C between the two groups(P>0.05).After treatment,the levels of HMGB1,IL-6,NF-κB and IL-10 in the two groups were lower than those before treatment,and lower in the combination group than in the Western medicine group(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Acupuncture at well points along the twelve meridians combined with Western medicine in the treatment of epilepsy can improve patients'epileptic seizures,enhance curative effect,inhibit inflammatory response,and do not affect blood lipid metabolism,which is safe to a certain extent.
作者
邢鑫
石会
孙淑贤
黄素玲
张涛
XING Xin;SHI Hui;SUN Shuxian;HUANG Suling;ZHANG Tao(Department of Neurology,Shijiazhuang Hospital of Traditional Chinese Medicine,Shijiazhuang 050000,China;Department of Laboratory,Shijiazhuang Hospital of Traditional Chinese Medicine,Shijiazhuang 050000,China;Department of Medical Reform,Shijiazhuang Hospital of Traditional Chinese Medicine,Shijiazhuang 050000,China)
出处
《临床误诊误治》
CAS
2023年第4期110-114,共5页
Clinical Misdiagnosis & Mistherapy
基金
河北省中医药管理局科研计划项目(2022170)。
