摘要
目的:探讨2型糖尿病(T2DM)患者血清羧化不全骨钙素(ucOC)水平与糖、脂代谢的相关性。方法:选取81例T2DM患者设为病例组,检测血清ucOC水平,根据中位ucOC水平分为两个亚组,≥中位ucOC水平的41例T2DM患者设为高ucOC组,<中位ucOC水平的40例T2DM患者设为低ucOC组;选取同期性别、年龄配对的40名健康体检者设为对照组。比较各组糖化血红蛋白(HbAlc)、空腹血糖(FPG)等糖代谢指标,总胆固醇(TC)、甘油三脂(TG)等脂代谢指标,并采用Pearson分析血清ucOC水平与糖、脂代谢指标的相关性。结果:高ucOC组、低ucOC组体质量指数(BMI)大于对照组,FCP、FBG、FINS、TG、LDL-C水平及HbA1c、HOMA-IR均高于对照组,血清ucOC、HDL-C水平及HOMA-β低于对照组;差异均有统计学意义(P<0.05)。低ucOC组BMI大于高ucOC组,平均病程长于高ucOC组,FCP、FINS、TG水平及HOMA-IR均高于高ucOC组,差异均有统计学意义(P<0.05)。血清ucOC与FCP、FINS、TG水平及HOMA-IR、HOMA-β均呈负相关关系(P<0.001)。结论:T2DM患者血清ucOC水平与糖脂代谢呈负相关关系。
Objective:To explore the correlation between serum carboxylated incomplete osteocalcin(ucOC)level and glucose and lipid metabolism in patients with type 2 diabetes mellitus(T2DM).Methods:81 T2DM patients were selected as the case group,and the serum ucOC level was measured.According to the median ucOC level,they were divided into two subgroups.41 T2DM patients with≥median ucOC level were set as the high ucOC group,and 40 T2DM patients with<median ucOC level were set as the low ucOC group.In the same period,40 health examinees matched by sex and age were set as the control group.Glycosylated hemoglobin(HbAlc),fasting blood glucose(FPG)and other indicators of glucose metabolism,total cholesterol(TC),triglyceride(TG)and other indicators of lipid metabolism were compared in each group.Pearson was used to analyze the correlation between serum ucOC level and indicators of glucose and lipid metabolism.Results:The body mass index(BMI)of high and low ucOC groups was higher than that of control group,the levels of FCP,FBG,FINS,TG,LDL-C,HbA1c and HOMA-IR were higher than those of control group,and the serum levels of ucOC,HDL-C and HOMA-βwere lower than those of control group.The differences were statistically significant(P<0.05).BMI of low ucOC group was higher than that of high ucOC group,average course of disease was longer than that of high ucOC group,FCP,FINS,TG levels and HOMA-IR were higher than those of high ucOC group.The differences were statistically significant(P<0.05).Serum ucOC levels were negatively correlated with FCP,FINS,TG levels,HOMA-IR and HOMA-β(P<0.001).Conclusion:Serum ucOC level in T2DM patients is negatively correlated with glucolipid metabolism.
作者
赵春楠
耿学丽
张泽智
郭轶群
赵维川
苏东峰
ZHAO Chun-nan;GENG Xue-li;ZHANG Ze-zhi;GUO Yi-qun;ZHAO Wei-chuan;SU Dong-feng(Department of Clinical Laboratory,Affiliated Hospital of Chengde Medical College,Chengde 067000,Hebei,China;Department of Endocrinology,Affiliated Hospital of Chengde Medical College,Chengde 067000,Hebei,China)
出处
《川北医学院学报》
CAS
2023年第4期484-487,共4页
Journal of North Sichuan Medical College
基金
河北省承德市科技支撑计划项目(201904A034)。
