摘要
代谢相关脂肪性肝病(MAFLD)是全球慢性肝病的重要病种,它的范围包括从简单的肝脏脂肪变性到脂肪性肝炎以及潜在的肝硬化和肝癌。MAFLD也是2型糖尿病、心血管疾病的独立危险因素。目前,尚无正式批准的特效西药可运用于MAFLD的临床治疗。在现代医学科技日新月异的大时代背景下,中药治疗MAFLD作用机制的研究也在不断突破和前进,并受到广泛关注和认可。综述了中药治疗代谢相关脂肪性肝病的相关作用机制研究进展,以期为MAFLD的临床治疗提供指导。
Metabolism associated fatty liver disease(MAFLD)is an important cause of chronic liver disease in the world,which ranges from simple hepatic steatosis to steatohepatitis,potential cirrhosis and hepatocellular carcinoma.MAFLD is also an independent risk factor for type 2 diabetes and cardiovascular diseases.At present,no officially approved potent drugs are available for the clinical treatment of MAFLD.In the context of the rapid development in modern medical science and technology,the research on the mechanism of action of traditional Chinese herbal medicines for treating MAFLD is advancing,continues to make breakthroughs,and has received wide attention and recognition.Therefore,with a view to providing guidance for the clinical treatment of MAFLD,we reviewed the research progress on the mechanism of action of traditional Chinese herbal medicines for treating MAFLD.
作者
李振
祝峻峰
LI Zhen;ZHU Junfeng(Department of Hepatology,Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200437,China)
出处
《上海中医药杂志》
CSCD
2023年第2期8-13,共6页
Shanghai Journal of Traditional Chinese Medicine
基金
国家自然科学基金项目(82074386)
上海申康医院发展中心临床三年行动计划资助项目(SHDC2020CR3095B)。
关键词
代谢相关脂肪性肝病
中药
胰岛素抵抗
脂质代谢
肠道菌群
作用机制
研究进展
metabolic associated fatty liver disease
traditional Chinese herbal medicine
insulin resistance
lipid metabolism
intestinal microflora
mechanism of action
research progress
